Western Blot (WB)
(SDCBP Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SDCBP antibody detected the SDCBP protein (arrow).)
Rabbit SDCBP Polyclonal Antibody | anti-SDCBP antibody
SDCBP Antibody (N-term)
Western Blot (WB)
(SDCBP Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SDCBP antibody detected the SDCBP protein (arrow).)
Western Blot (WB)
(SDCBP Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SDCBP antibody detected the SDCBP protein (arrow).)
as a molecule linking syndecan-mediated signaling to the
cytoskeleton. The syntenin protein contains tandemly repeated PDZ
domains that bind the cytoplasmic, C-terminal domains of a variety
of transmembrane proteins. This protein may also affect
cytoskeletal-membrane organization, cell adhesion, protein
trafficking, and the activation of transcription factors. The
protein is primarily localized to membrane-associated adherens
junctions and focal adhesions but is also found at the endoplasmic
reticulum and nucleus. Alternative splicing results in multiple
transcript variants encoding different isoforms. [provided by
RefSeq].
Qian, X.L., et al. Yi Chuan 32(3):235-241(2010)
Hwangbo, C., et al. Cancer Res. 70(4):1645-1655(2010)
Beekman, J.M., et al. Blood 114(18):3917-3927(2009)
Sira, M.M., et al. Int. Immunol. 21(9):1013-1023(2009)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
syntenin: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine; Cell adhesion; Vesicle; Motility/polarity/chemotaxis; Membrane protein, integral; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 8q12
Cellular Component: extracellular space; endoplasmic reticulum membrane; adherens junction; cytoskeleton; focal adhesion; membrane; cytoplasm; plasma membrane; interleukin-5 receptor complex; melanosome; nucleus; cytosol; vesicle
Molecular Function: protein C-terminus binding; syndecan binding; identical protein binding; protein homodimerization activity; ephrin receptor binding; protein N-terminus binding; interleukin-5 receptor binding; protein binding; protein heterodimerization activity; frizzled binding; neurexin binding; growth factor binding; cell adhesion molecule binding; cytoskeletal adaptor activity; glycoprotein binding
Biological Process: synaptic transmission; axon guidance; Ras protein signal transduction; ephrin receptor signaling pathway; positive regulation of JNK cascade; actin cytoskeleton organization and biogenesis; protein targeting to membrane; substrate-bound cell migration, cell extension; positive regulation of phosphorylation
Research Articles on SDCBP
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Product Notes
The SDCBP sdcbp (Catalog #AAA9204695) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The SDCBP Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's SDCBP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SDCBP sdcbp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SDCBP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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