Rabbit anti-Human SDC4 Polyclonal Antibody | anti-SDC4 antibody

SDC4 (SYND4, Amphiglycan, Ryudocan Core Protein, Syndecan-4, MGC22217) (Biotin)

Cat. Num. AAA6393466

• Gene Names: SDC4; SYND4
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SDC4; Polyclonal Antibody; SDC4 (SYND4; Amphiglycan; Ryudocan Core Protein; Syndecan-4; MGC22217) (Biotin); anti-SDC4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SDC4.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-SDC4 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human SDC4, aa1-198 (NP_002990.2).
• Immunogen Sequence: MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAALIVGGIVGILFAVFLILLLMYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of SDC4 expression in transfected 293T cell line by SDC4 polyclonal antibody. Lane 1: SDC4 transfected lysate (21.6kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-SDC4 antibody

Syndecan-4 is a transmembrane (type I) heparan sulfate proteoglycan containing 198aa and belonging to the syndecan proteoglycan family. Syndecan-4 functions as a receptor or coreceptor in intracellular signaling. Initially, Syndecan-4 was isolated as ryudocan, from rat endothelial cells, and from human epithelial and fibroblastic cells, as amphiglycan. The syndecan heparan sulfate chains of Syndecan-4 binds to HIV-1 gp120 and thus functions as trans HIV receptors. This cell surface proteoglycan usually exists as a homodimer that interacts with CDCP1, with GIPC PDZ domain and with NUDT16L1/SDOS. Reports suggest that Syndecan-4 is often upregulated in skin dermis after wounding, thus playing an important role in wound healing and angiogenesis. It is also needed in satellite cell function and in the development and regeneration of skeletal muscle.

Product Categories/Family for anti-SDC4 antibody

Antibodies; Carbohydrates; Glycoproteins

NCBI and Uniprot Product Information

• NCBI GI #: 38201675
• NCBI GeneID: 6385
• NCBI Accession #: NP_002990.2
• NCBI GenBank Nucleotide #: NM_002999.2
• UniProt Accession #: P31431; O00773; Q16833; Q53FN9; Q6FGN3
• Molecular Weight: 21,642 Da
• NCBI Official Full Name: syndecan-4
• NCBI Official Synonym Full Names: syndecan 4
• NCBI Official Symbol: SDC4
• NCBI Official Synonym Symbols: SYND4
• NCBI Protein Information: syndecan-4; amphiglycan; ryudocan amphiglycan; ryudocan core protein; syndecan proteoglycan 4; syndecan 4 (amphiglycan, ryudocan)
• UniProt Protein Name: Syndecan-4
• Protein Family: Syndecan
• UniProt Gene Name: SDC4
• UniProt Synonym Gene Names: SYND4
• UniProt Entry Name: SDC4_HUMAN

NCBI Description

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Uniprot Description

syndecan-4: a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Expressed as a homodimer. Promotes cell spreading in a beta(1) integrin-dependent fashion through PKC-alpha and Rho.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: lysosomal lumen; focal adhesion; costamere; cell surface; Golgi lumen; integral to plasma membrane; plasma membrane; lipid raft

Molecular Function: protein binding; protein kinase C binding; fibronectin binding

Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; phototransduction, visible light; extracellular matrix organization and biogenesis; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; positive regulation of focal adhesion formation; ureteric bud development; positive regulation of protein kinase activity; positive regulation of stress fiber formation; carbohydrate metabolic process; pathogenesis; retinoid metabolic process