Rabbit anti-Human SCYL1 Polyclonal Antibody | anti-SCYL1 antibody

SCYL1 antibody

Cat. Num. AAA9414440

• Gene Names: SCYL1; GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: SCYL1; Polyclonal Antibody; SCYL1 antibody; GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019; anti-SCYL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total SCYL1 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 791

• Applicable Applications for anti-SCYL1 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunofluorescence: 1:50 - 1:100
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human SCYL1.
• Target Name: SCYL1
• Preparation and Storage: Store at -20 degree C

Immunofluorescence (IF)

(Immunofluorescence analysis of MCF-7 cell using SCYL1 antibody. Blue: DAPI for nuclear staining.)

Related Product Information for anti-SCYL1 antibody

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-SCYL1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 115430243
• NCBI GeneID: 57410
• NCBI Accession #: NP_001041683.1
• NCBI GenBank Nucleotide #: NM_001048218.1
• UniProt Accession #: Q96KG9; Q96G50; Q96KG8; Q96KH1; Q9HAW5; Q9HBL3; Q9NR53; A6NJF1
• Molecular Weight: 86,371 Da
• NCBI Official Full Name: N-terminal kinase-like protein isoform B
• NCBI Official Synonym Full Names: SCY1-like, kinase-like 1
• NCBI Official Symbol: SCYL1
• NCBI Official Synonym Symbols: GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019
• NCBI Protein Information: N-terminal kinase-like protein
• UniProt Protein Name: N-terminal kinase-like protein
• Protein Family: N-terminal kinase-like protein
• UniProt Gene Name: SCYL1
• UniProt Synonym Gene Names: CVAK90; GKLP; NTKL; TAPK; TEIF; TRAP
• UniProt Entry Name: NTKL_HUMAN

NCBI Description

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SCYL1: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. Belongs to the protein kinase superfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; SCY1 family

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi apparatus; cis-Golgi network; membrane; cytoplasm; ER-Golgi intermediate compartment; microtubule organizing center; COPI vesicle coat; nucleus

Molecular Function: DNA binding; protein-tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; retrograde vesicle-mediated transport, Golgi to ER