Rabbit SCN2A Polyclonal Antibody | anti-SCN2A antibody

SCN2A Antibody

Cat. Num. AAA9408155

• Gene Names: SCN2A; HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: SCN2A; Polyclonal Antibody; SCN2A Antibody; HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2; anti-SCN2A antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total SCN2A protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.8 mg/ml (varies by lot)
• Sequence Length: 2005

• Applicable Applications for anti-SCN2A antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human sodium channel, voltage-gated, type II, alpha subunit
• Target Name: SCN2A
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/25.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/25.)

Related Product Information for anti-SCN2A antibody

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Product Categories/Family for anti-SCN2A antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 93141212
• NCBI GeneID: 6326
• NCBI Accession #: NP_001035232.1
• NCBI GenBank Nucleotide #: NM_001040142.1
• UniProt Accession #: Q99250; Q14472; Q53T77; Q9BZC9; Q9BZD0; A6NC14; A6NIQ5
• Molecular Weight: 227,974 Da
• NCBI Official Full Name: sodium channel protein type 2 subunit alpha isoform 1
• NCBI Official Synonym Full Names: sodium channel, voltage gated, type II alpha subunit
• NCBI Official Symbol: SCN2A
• NCBI Official Synonym Symbols: HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2
• NCBI Protein Information: sodium channel protein type 2 subunit alpha
• UniProt Protein Name: Sodium channel protein type 2 subunit alpha
• Protein Family: Sodium channel protein
• UniProt Gene Name: SCN2A
• UniProt Synonym Gene Names: NAC2; SCN2A1; SCN2A2
• UniProt Entry Name: SCN2A_HUMAN

NCBI Description

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

SCN2A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Defects in SCN2A are the cause of seizures, benign familial infantile type 3 (BFIS3). An autosomal dominant disorder in which afebrile seizures occur in clusters during the first year of life, without neurologic sequelae. Defects in SCN2A are the cause of epileptic encephalopathy early infantile type 11 (EIEE11). EIEE11 is an autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, sodium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q24.3

Cellular Component: voltage-gated sodium channel complex; integral to plasma membrane; axon; T-tubule; paranode region of axon; plasma membrane; intrinsic to plasma membrane

Molecular Function: voltage-gated sodium channel activity

Biological Process: myelination; neuron apoptosis; induction of apoptosis by ionic changes; sodium ion transport; generation of action potential

Disease: Seizures, Benign Familial Infantile, 3; Epileptic Encephalopathy, Early Infantile, 11