Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using SCN2A Polyclonal Antibody at dilution 1:40)
Rabbit SCN2A Polyclonal Antibody | anti-SCN2A antibody
SCN2A Polyclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using SCN2A Polyclonal Antibody at dilution 1:40)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using SCN2A Polyclonal Antibody at dilution 1:40)
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
SCN2A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Defects in SCN2A are the cause of seizures, benign familial infantile type 3 (BFIS3). An autosomal dominant disorder in which afebrile seizures occur in clusters during the first year of life, without neurologic sequelae. Defects in SCN2A are the cause of epileptic encephalopathy early infantile type 11 (EIEE11). EIEE11 is an autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2q24.3
Cellular Component: voltage-gated sodium channel complex; integral to plasma membrane; axon; paranode region of axon; T-tubule; plasma membrane; intrinsic to plasma membrane
Molecular Function: voltage-gated sodium channel activity
Biological Process: myelination; neuron apoptosis; induction of apoptosis by ionic changes; sodium ion transport; generation of action potential
Disease: Seizures, Benign Familial Infantile, 3; Epileptic Encephalopathy, Early Infantile, 11
Research Articles on SCN2A
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Product Notes
The SCN2A scn2a (Catalog #AAA2529701) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SCN2A Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SCN2A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). IHC: 1:25-1:100. Researchers should empirically determine the suitability of the SCN2A scn2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCN2A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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