Rabbit anti-Human, Mouse SCARA5 Polyclonal Antibody | anti-SCARA5 antibody

SCARA5 Antibody

Cat. Num. AAA9404242

• Gene Names: SCARA5; Tesr; NET33
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunocytochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: SCARA5; Polyclonal Antibody; SCARA5 Antibody; Scavenger receptor class A member 5; TESR; anti-SCARA5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 495

• Applicable Applications for anti-SCARA5 antibody: ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 17 amino acid peptide near the carboxy terminus of human SCARA5.
• Target Name: SCARA5
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SCARA5 in human liver tissue lysate with SCARA5 antibody at 1 ug/mL.)

Immunocytochemistry (ICC)

(Immunocytochemistry of SCARA5 in HepG2 cells with SCARA5 antibody at 2.5 ug/mL.)

Related Product Information for anti-SCARA5 antibody

Scavenger receptor class A member 5 (SCARA5), also known as TESR, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARA5 is a cell-surface receptor that contains that collagen-like domain and N-terminal scavenger receptor cysteine rich domain typical of the class A scavenger receptor subfamily. Unlike other class A receptors, SCARA5 does not endocytose acetylated or oxidized low density lipoprotein. Instead, SCARA5 binds serum ferritin and mediates its endocytosis from the cell surface, indicating SCARA5 may play a role in non-transferrin iron delivery. At least four isoforms of SCARB1 are known to exist.

Product Categories/Family for anti-SCARA5 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 47271477
• NCBI GeneID: 286133
• NCBI Accession #: NP_776194
• NCBI GenBank Nucleotide #: NM_173833.5
• Molecular Weight: 28,871 Da
• NCBI Official Full Name: scavenger receptor class A member 5
• NCBI Official Synonym Full Names: scavenger receptor class A, member 5
• NCBI Official Symbol: SCARA5
• NCBI Official Synonym Symbols: Tesr; NET33
• NCBI Protein Information: scavenger receptor class A member 5
• UniProt Protein Name: Scavenger receptor class A member 5
• Protein Family: Scavenger receptor
• UniProt Gene Name: SCARA5
• UniProt Entry Name: SCAR5_HUMAN

Uniprot Description

SCARA5: Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1). Belongs to the SCARA5 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21.1

Cellular Component: cell surface; integral to plasma membrane

Molecular Function: scavenger receptor activity

Biological Process: receptor-mediated endocytosis; regulation of gene expression; cellular iron ion homeostasis; regulation of blood coagulation; endocytosis