Rabbit anti-Human, Mouse SARM1 Polyclonal Antibody | anti-SARM1 antibody

SARM1 (Sterile alpha and TIR motif containing 1)

Cat. Num. AAA614284

• Gene Names: SARM1; SARM; SAMD2; FLJ36296; KIAA0524
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Highly Purified; Purified by Ion Exchange chromatography.
• Synonyms: SARM1; Polyclonal Antibody; SARM1 (Sterile alpha and TIR motif containing 1); Anti -SARM1 (Sterile alpha and TIR motif containing 1); anti-SARM1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SARM1. SARM1 contains a Toll-interleukin-1 (TIR) domain, and is reported to serve as an adaptor protein for the Toll-like receptors during the innate immune response. Species Cross Reactivity: mouse
• Purity/Purification: Highly Purified; Purified by Ion Exchange chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.

• Applicable Applications for anti-SARM1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 0.5-2ug/ml. Detects a band of ~80kD in Daudi cell lysates.; Optimal dilution determined by the researcher.
• Immunogen: Synthetic peptide corresponding to a region within the C-Terminus of human SARM1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-SARM1 antibody

SARM1 contains a Toll-interleukin-1 (TIR) domain, and is reported to serve as an adaptor protein for the Toll-like receptors during the innate immune response.

Product Categories/Family for anti-SARM1 antibody

Antibodies; Abs to Toll Like Receptors (TLR)

NCBI and Uniprot Product Information

• NCBI GI #: 154090976
• NCBI GeneID: 23098
• NCBI Accession #: NP_055892.2
• NCBI GenBank Nucleotide #: NM_015077.2
• UniProt Accession #: Q6SZW1; O60277; Q7LGG3; Q9NXY5; Q05B42; Q0D2N8
• Molecular Weight: 79,388 Da
• NCBI Official Full Name: sterile alpha and TIR motif-containing protein 1
• NCBI Official Synonym Full Names: sterile alpha and TIR motif containing 1
• NCBI Official Symbol: SARM1
• NCBI Official Synonym Symbols: SARM; SAMD2; FLJ36296; KIAA0524
• NCBI Protein Information: sterile alpha and TIR motif-containing protein 1; tir-1 homolog; OTTHUMP00000163322; SAM domain-containing protein 2; sterile alpha and Armadillo repeat protein; sterile alpha motif domain-containing protein 2; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
• UniProt Protein Name: Sterile alpha and TIR motif-containing protein 1
• Protein Family: Sterile alpha and TIR motif-containing protein
• UniProt Gene Name: SARM1
• UniProt Synonym Gene Names: KIAA0524; SAMD2; SARM
• UniProt Entry Name: SARM1_HUMAN

Uniprot Description

SARM1: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: microtubule; mitochondrion; axon; cytoplasm; dendrite; extrinsic to mitochondrial outer membrane; synapse; cell junction; cytosol

Biological Process: regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of dendrite morphogenesis; toll-like receptor signaling pathway; response to glucose stimulus; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway