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Rabbit anti-Mouse SAG Polyclonal Antibody | anti-SAG antibody

SAG (S-arrestin, 48kD Protein, Retinal S-antigen, S-AG, Rod Photoreceptor Arrestin, SAG) (MaxLight 650)

Gene Names
SAG; RP47; S-AG
Reactivity
Mouse
Applications
Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
SAG; Polyclonal Antibody; SAG (S-arrestin; 48kD Protein; Retinal S-antigen; S-AG; Rod Photoreceptor Arrestin; SAG) (MaxLight 650); anti-SAG antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes mouse SAG. Species Crossreactivity: mouse
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Applicable Applications for anti-SAG antibody
Western Blot (WB)
Application Notes
WB: 1:2000
Applications are based on unconjugated antibody.
Immunogen
KLH conjugated synthetic peptide corresponding to aa273-307 at the human SAG.
Conjugate
MaxLight650
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Product Categories/Family for anti-SAG antibody
References
Yamaki K., et al. FEBS Lett. 234:39-43(1988). Yamaki K., et al. FEBS Lett. 236:507-507(1988). Yamamoto S., et al. Nat. Genet. 15:175-178(1997). Hillier L.W., et al. Nature 434:724-731(2005). Roni V., et al. BMC Genomics 8:42-42(2007).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
45,120 Da
NCBI Official Full Name
S-arrestin
NCBI Official Synonym Full Names
S-antigen; retina and pineal gland (arrestin)
NCBI Official Symbol
SAG
NCBI Official Synonym Symbols
RP47; S-AG
NCBI Protein Information
S-arrestin
UniProt Protein Name
S-arrestin
Protein Family
UniProt Gene Name
SAG
UniProt Synonym Gene Names
S-AG
UniProt Entry Name
ARRS_HUMAN

NCBI Description

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008]

Uniprot Description

SAG: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Retina and pineal gland. Belongs to the arrestin family.

Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: cytosol; photoreceptor inner segment; photoreceptor outer segment

Molecular Function: opsin binding; phosphoprotein binding; protein phosphatase inhibitor activity

Biological Process: cell surface receptor linked signal transduction; negative regulation of catalytic activity; phototransduction, visible light; regulation of rhodopsin mediated signaling; rhodopsin mediated signaling; visual perception

Disease: Oguchi Disease 1; Retinitis Pigmentosa 47

Research Articles on SAG

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Product Notes

The SAG sag (Catalog #AAA6459019) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SAG (S-arrestin, 48kD Protein, Retinal S-antigen, S-AG, Rod Photoreceptor Arrestin, SAG) (MaxLight 650) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SAG can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:2000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SAG sag for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SAG, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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