Western Blot (WB)
(Mouse Rps6kb1 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the Rps6kb1 antibody detected the Rps6kb1 protein (arrow).)
Rabbit Rps6kb1 Polyclonal Antibody | anti-Rps6kb1 antibody
Mouse Rps6kb1 Antibody (C-term)
Western Blot (WB)
(Mouse Rps6kb1 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the Rps6kb1 antibody detected the Rps6kb1 protein (arrow).)
Western Blot (WB)
(Mouse Rps6kb1 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the Rps6kb1 antibody detected the Rps6kb1 protein (arrow).)
Western Blot (WB)
(Mouse Rps6kb1 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Rps6kb1 antibody detected the Rps6kb1 protein (arrow).)
Western Blot (WB)
(Mouse Rps6kb1 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Rps6kb1 antibody detected the Rps6kb1 protein (arrow).)
Michels, A.A., et al. Mol. Cell. Biol. 30(15):3749-3757(2010)
Witkowski, S., et al. FEBS Lett. 584(13):2891-2895(2010)
Carnevalli, L.S., et al. Dev. Cell 18(5):763-774(2010)
Hamilton, D.L., et al. BMC Cell Biol. 11, 37 (2010) :
NCBI and Uniprot Product Information
Uniprot Description
p70S6K: an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported.
Protein type: Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Translation; AGC group; RSK family; p70 subfamily
Cellular Component: nucleoplasm; mitochondrial outer membrane; neuron projection; cell surface; membrane; mitochondrion; perinuclear region of cytoplasm; cytoplasm; synapse; intracellular; cell junction; nucleus
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; protein serine/threonine/tyrosine kinase activity; kinase activity; ribosomal protein S6 kinase activity; peptide binding; ATP binding; protein kinase activity
Biological Process: TOR signaling pathway; behavioral fear response; positive regulation of translation; apoptosis; positive regulation of smooth muscle cell proliferation; negative regulation of insulin receptor signaling pathway; cell cycle; signal transduction; positive regulation of mitotic cell cycle; positive regulation of smooth muscle cell migration; protein amino acid phosphorylation; germ cell development; response to insulin stimulus; positive regulation of translational initiation; regulation of translation; cellular response to insulin stimulus; protein kinase B signaling cascade; regulation of glucose import; positive regulation of skeletal muscle growth; phosphorylation; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Research Articles on Rps6kb1
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Product Notes
The Rps6kb1 rps6kb1 (Catalog #AAA9204564) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 481-509. The Mouse Rps6kb1 Antibody (C-term) reacts with Human, mouse (Predicted Reactivity: Bovine, Rabbit, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Rps6kb1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Rps6kb1 rps6kb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Rps6kb1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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