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Immunohistochemistry (IHC) (Anti-RCAN2 antibody IHC of human endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.)

Rabbit RCAN2 / RCN2 Polyclonal Antibody | anti-RCAN2 antibody

Rabbit Polyclonal to Human RCAN2 / RCN2

Gene Names
RCAN2; CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Immunoaffinity Purified
Synonyms
RCAN2 / RCN2; Polyclonal Antibody; Rabbit Polyclonal to Human RCAN2 / RCN2; Anti-RCAN2 / RCN2 Antibody (Internal) IHC-plus; RCAN2; Calcipressin-2; CSP2; DSCR1L1; HRCN2; ZAKI-4; ZAKI4; MCIP2; Regulator of calcineurin 2; Human RCAN2; RCN2; anti-RCAN2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
Human RCAN2
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.02% sodium azide
Concentration
1 mg/ml (varies by lot)
Sequence Length
197
Applicable Applications for anti-RCAN2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes
ELISA, IHC-P (3 ug/ml), WB (1 - 2 ug/ml)
Usage: RCAN2 antibody can be used for detection of RCAN2 by Western blot at 1-2 ug/ml.
Target Species
Human
Immunogen Description
A 14 amino acid peptide near the center of human RCAN2.
Immunogen Type
Synthetic peptide
Immunogen
RCAN2 / RCN2 antibody was raised against a 14 amino acid peptide near the center of human RCAN2.
Antigen Modification
Internal
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-RCAN2 antibody IHC of human endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.)

Immunohistochemistry (IHC) (Anti-RCAN2 antibody IHC of human endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.)

Immunohistochemistry (IHC)

(Anti-RCAN2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.)

Immunohistochemistry (IHC) (Anti-RCAN2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of RCAN2 in mouse brain tissue with RCAN2 antibody at 20 ug/ml.)

Immunofluorescence (IF) (Immunofluorescence of RCAN2 in mouse brain tissue with RCAN2 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot of RCAN2 in 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 ug/ml.)

Western Blot (WB) (Western blot of RCAN2 in 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 ug/ml.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
27,289 Da
NCBI Official Full Name
calcipressin-2 isoform 1
NCBI Official Synonym Full Names
regulator of calcineurin 2
NCBI Official Symbol
RCAN2
NCBI Official Synonym Symbols
CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1
NCBI Protein Information
calcipressin-2; Down syndrome candidate region 1-like 1; thyroid hormone-responsive protein ZAKI-4; Down syndrome critical region gene 1-like 1; thyroid hormone-responsive (skin fibroblasts); myocyte-enriched calcineurin-interacting protein 2
UniProt Protein Name
Calcipressin-2
Protein Family
UniProt Gene Name
RCAN2
UniProt Synonym Gene Names
DSCR1L1; ZAKI4; MCIP2
UniProt Entry Name
RCAN2_HUMAN

NCBI Description

This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

RCAN2: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6p12.3

Molecular Function: nucleotide binding

Biological Process: calcineurin-NFAT signaling pathway; short-term memory; response to oxidative stress; locomotion during locomotory behavior

Research Articles on RCAN2

Similar Products

Product Notes

The RCAN2 rcan2 (Catalog #AAA247453) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human RCAN2 / RCN2 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's RCAN2 / RCN2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA). ELISA, IHC-P (3 ug/ml), WB (1 - 2 ug/ml) Usage: RCAN2 antibody can be used for detection of RCAN2 by Western blot at 1-2 ug/ml. Researchers should empirically determine the suitability of the RCAN2 rcan2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RCAN2 / RCN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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