Rabbit anti-Human RBM3 Polyclonal Antibody | anti-RBM3 antibody

RBM3 Polyclonal Antibody

Cat. Num. AAA2563536

• Gene Names: RBM3; RNPL; IS1-RNPL
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity purification
• Synonyms: RBM3; Polyclonal Antibody; RBM3 Polyclonal Antibody; 2600016C11Rik; IS1 RNPL; MGC105811; MGC118410; Putative RNA binding protein 3; Putative RNA-binding protein 3; Rbm3; RNA binding motif (RNP1; RRM) protein 3; RNA binding motif protein 3; RNA-binding motif protein 3; RNA-binding protein 3; RNPL; RP23-27I6.7; anti-RBM3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
• Concentration: 2mg/mL (varies by lot)
• Sequence Length: 157

• Applicable Applications for anti-RBM3 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:400
• Immunogen: Recombinant Human RNA-binding protein 3 protein
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20?. Avoid freeze/ thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human lung cancer using RBM3 Polyclonal Antibody at dilution of 1:100)

Related Product Information for anti-RBM3 antibody

RBM3, also named as RNPL, is a cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. It reduces the relative abundance of microRNAs, when overexpressed. RBM3 enhances phosphoryaltion of translation initiation factors and active polysome formation. It is up-regulated in human tumors. RBM3 is a potential proto-oncogenic proteins upon overexpression.

Product Categories/Family for anti-RBM3 antibody

Cancer, Epigenetics and Nuclear Signaling, Metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 5803137
• NCBI GeneID: 5935
• NCBI Accession #: NP_006734.1
• NCBI GenBank Nucleotide #: NP_006734.1
• UniProt Accession #: P98179
• NCBI Official Full Name: RNA-binding protein 3
• NCBI Official Synonym Full Names: RNA binding motif protein 3
• NCBI Official Symbol: RBM3
• NCBI Official Synonym Symbols: RNPL; IS1-RNPL
• NCBI Protein Information: RNA-binding protein 3
• UniProt Protein Name: RNA-binding protein 3
• Protein Family: RNA-binding protein
• UniProt Gene Name: RBM3
• UniProt Synonym Gene Names: RNPL
• UniProt Entry Name: RBM3_HUMAN

NCBI Description

This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]

Uniprot Description

RBM3: Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation.

Protein type: Ribosomal; Translation; RNA-binding; RNA processing

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: cytoplasm; dendrite; nucleus; large ribosomal subunit

Molecular Function: protein binding; RNA binding; nucleotide binding; ribosomal large subunit binding

Biological Process: RNA processing; regulation of translation; miRNA-mediated gene silencing, production of miRNAs; positive regulation of translation; translation; response to cold