ROMK/Kir1.1 Antibody | anti-ROMK/Kir1.1 antibody

ROMK/Kir1.1 (Ab-44/25) Antibody

Cat. Num. AAA859790

• Gene Names: KCNJ1; ROMK; ROMK1; KIR1.1
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: ROMK/Kir1.1; ROMK/Kir1.1 (Ab-44/25) Antibody; ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; IRK1; KAB-1; KCNJ1; Kir1.1; Potassium channel; inwardly rectifying; subfamily J; member 1; ROMK1; anti-ROMK/Kir1.1 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: ROMK/Kir1.1 antibody detects endogenous levels of total ROMK/Kir1.1 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 391

• Applicable Applications for anti-ROMK/Kir1.1 antibody: Immunofluorescence (IF), ELISA (EIA)
• Application Notes: IF: 1:100-1:500; ELISA: 1:1000
• Immunogen: The antiserum was produced against synthesized peptide derived from Internal of human ROMK/Kir1.1.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunofluorescence (IF)

(Peptide-+ Immunofluorescence analysis of A549 cells, using ROMK/Kir1.1 antibody.)

Product Categories/Family for anti-ROMK/Kir1.1 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Shuck M.E., J. Biol. Chem. 269:24261-24270(1994). Yano H., Mol. Pharmacol. 45:854-860(1994). Bock J.H., Gene 188-9-16(1997).

NCBI and Uniprot Product Information

• NCBI GI #: 4504837
• NCBI GeneID: 3758
• NCBI Accession #: NP_000211.1
• NCBI GenBank Nucleotide #: NM_000220.4
• UniProt Accession #: P48048; Q6LD67; B2RMR4
• Molecular Weight: 44,611 Da
• NCBI Official Full Name: ATP-sensitive inward rectifier potassium channel 1 isoform a
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily J member 1
• NCBI Official Symbol: KCNJ1
• NCBI Official Synonym Symbols: ROMK; ROMK1; KIR1.1
• NCBI Protein Information: ATP-sensitive inward rectifier potassium channel 1
• UniProt Protein Name: ATP-sensitive inward rectifier potassium channel 1
• UniProt Gene Name: KCNJ1
• UniProt Synonym Gene Names: ROMK1

NCBI Description

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.