Rabbit anti-Human RALBP1 Polyclonal Antibody | anti-RALBP1 antibody

Anti-Human RALBP1 DyLight 488 conjugated Antibody

Cat. Num. AAA1751345

• Gene Names: RALBP1; RIP1; RLIP1; RLIP76
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Immunogen Affinity Purified
• Synonyms: RALBP1; Polyclonal Antibody; Anti-Human RALBP1 DyLight 488 conjugated Antibody; Rabbit IgG Polyclonal Anti-Human RALBP1 Antibody DyLight 488 Conjugated; Flow Validated; RalA-binding protein 1; RalBP1; 76 kDa Ral-interacting protein; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1; RLIP1; RLIP76; RalA binding protein 1; anti-RALBP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins.
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 655

• Applicable Applications for anti-RALBP1 antibody: Flow Cytometry (FC/FACS)
• Application Notes: FC/FACS: 1-3ug/1x106 cells
• Immunogen: E Coli-derived human RALBP1 recombinant protein (Position: K239-Q506).
• Preparation and Storage: Store at 2-8 degree C for one year. Protect from light. Do not freeze.

Related Product Information for anti-RALBP1 antibody

RalA-binding protein 1 is a protein that in humans is encoded by the RALBP1 gene. Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS, which in turn is activated by RAS. RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL. RALBP1 is also the dominant transporter of lipid peroxidation-derived glutathione conjugates and participates in several mitotic events, including inactivation of endocytosis and separation and polar movement of centrioles and appropriate distribution of mitochondria to daughter cells following mitosis.

References

1. "Entrez Gene: RALBP1 ralA binding protein 1". 2. Kashatus, D. F., Lim, K.-H., Brady, D. C., Pershing, N. L. K., Cox, A. D., Counter, C. M. RALA and RALBP1 regulate mitochondrial fission at mitosis. Nature Cell Biol. 13: 1108-1115, 2011.

NCBI and Uniprot Product Information

• NCBI GI #: 5803145
• NCBI GeneID: 10928
• NCBI Accession #: NP_006779.1
• NCBI GenBank Nucleotide #: NM_006788.4
• UniProt Accession #: Q15311; D3DUI0
• Molecular Weight: 76,063 Da
• NCBI Official Full Name: ralA-binding protein 1
• NCBI Official Synonym Full Names: ralA binding protein 1
• NCBI Official Symbol: RALBP1
• NCBI Official Synonym Symbols: RIP1; RLIP1; RLIP76
• NCBI Protein Information: ralA-binding protein 1
• UniProt Protein Name: RalA-binding protein 1
• Protein Family: RalA-binding protein
• UniProt Gene Name: RALBP1
• UniProt Synonym Gene Names: RLIP1; RLIP76; RalBP1; DNP-SG ATPase

NCBI Description

RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]

Uniprot Description

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.