Rabbit anti-Human RAC2 Polyclonal Antibody | anti-RAC2 antibody
RAC2 Antibody; HRP conjugated
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
Uniprot Description
RAC2: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Interacts with DOCK2, which may activate it. Hematopoietic specific. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Belongs to the small GTPase superfamily. Rho family.
Protein type: G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis; G protein, monomeric
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: actin filament; cytosol; focal adhesion; lamellipodium; nuclear envelope; phagocytic vesicle membrane; plasma membrane
Molecular Function: GTP binding; GTPase activity; protein kinase regulator activity
Biological Process: actin filament organization; axon guidance; blood coagulation; bone resorption; cell projection biogenesis; G-protein coupled receptor protein signaling pathway; platelet activation; positive regulation of cell proliferation; regulation of hydrogen peroxide metabolic process; regulation of mast cell degranulation; regulation of protein kinase activity; regulation of small GTPase mediated signal transduction; regulation of T cell proliferation; signal transduction; small GTPase mediated signal transduction
Disease: Neutrophil Immunodeficiency Syndrome
Research Articles on RAC2
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Product Notes
The RAC2 rac2 (Catalog #AAA7006431) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RAC2 Antibody; HRP conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RAC2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the RAC2 rac2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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