Mouse anti-Human RAB40C Polyclonal Antibody | anti-RAB40C antibody

RAB40C (Ras-related Protein Rab-40C, Rar-like Protein, RARL, Ras-like Protein Family Member 8C, RASL8C, SOCS Box-containing Protein RAR3)

Cat. Num. AAA648479

• Gene Names: RAB40C; RARL; RASL8C
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: RAB40C; Polyclonal Antibody; RAB40C (Ras-related Protein Rab-40C; Rar-like Protein; RARL; Ras-like Protein Family Member 8C; RASL8C; SOCS Box-containing Protein RAR3); Anti -RAB40C (Ras-related Protein Rab-40C; anti-RAB40C antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human RAB40C.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MGSQGSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGAAESPYAYSNGIDYKTTTILLDGRRVRLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSFDGIDRWIKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCNFNVIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTIKSHLKSFSMANGMNAVMMHGRSYSLASGAGGGGSKGNSLKRSKSIRPPQSPPQNCSRSNCKIS

• Applicable Applications for anti-RAB40C antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human RAB40C, aa1-281 (NP_066991.2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot detection against Immunogen (29.85kD).)

Testing Data

(Detection limit for recombinant GST tagged POLD4 is ~0.3ng/ml as a capture antibody.)

Product Categories/Family for anti-RAB40C antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 119606200
• NCBI GeneID: 57799
• UniProt Accession #: Q96S21; O60795; Q4TT41; A2IDE2; D3DU54
• Molecular Weight: 31,304 Da
• NCBI Official Full Name: RAB40C, member RAS oncogene family, isoform CRA_a
• NCBI Official Synonym Full Names: RAB40C, member RAS oncogene family
• NCBI Official Symbol: RAB40C
• NCBI Official Synonym Symbols: RARL; RASL8C
• NCBI Protein Information: ras-related protein Rab-40C; RAR like; RAS-like GTPase; rar-like protein; RAR (RAS like GTPASE) like; RAS-like, family 8, member C; SOCS box-containing protein RAR3; ras-like protein family member 8C
• UniProt Protein Name: Ras-related protein Rab-40C
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB40C
• UniProt Synonym Gene Names: RARL; RASL8C
• UniProt Entry Name: RB40C_HUMAN

Uniprot Description

Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ref.4

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and RAB40C. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Ref.4

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side

Potential.

Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes

By similarity.

Sequence similarities: Belongs to the small GTPase superfamily. Rab family.Contains 1 SOCS box domain.