Rabbit anti-Human RAB39B Polyclonal Antibody | anti-RAB39B antibody

Anti-RAB39B Antibody, Rabbit Polyclonal

Cat. Num. AAA8107936

• Reactivity: Human
• Applications: Immunohistochemistry, Immunocytochemistry, Immunofluorescence
• Purity: Protein A & Antigen Affinity
• Synonyms: RAB39B; Polyclonal Antibody; Anti-RAB39B Antibody; Rabbit Polyclonal; RAB39B Antibody; Rabbit PAb; Antigen Affinity Purified; member RAS oncogene family; Anti-MRX72 Antibody; Anti-WSMN Antibody; anti-RAB39B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human RAB39B
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-RAB39B antibody: Immunohistochemistry-Paraffin (IHC-P), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Application Notes: IHC-P: 1:50-1:200; ICC/IF: 1:100-1:500
• Immunogen: E Coli-derived Human RAB39B fragment
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with E Coli-derived Human RAB39B fragment, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human RAB39B in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining of human RAB39B in human stomach with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Immunofluorescence (IF)

(Immunofluorescence staining of RAB39B in SHSY5Y cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human RAB39B polyclonal antibody (dilution ratio 1:200) at 4 degree C overnight. Then cells were stained with the Alexa Fluor488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm.)

Related Product Information for anti-RAB39B antibody

RAB39B is a member of the Rab family of small GTPases that controls intracellular vesicular trafficking in a compartment-specific manner. RAB39B was expressed in a variety of human tissues and located in human chromosome Xq28. It consisted of two exons spanning 3764 bp of human genomic DNA. Mutations in the RAB39B gene cause intellectual disability comorbid with autism spectrum disorder and epilepsy. The resulting alteration in synaptic function underlies cognitive dysfunction in RAB39B-related disorders. RAB39B pathogenic variants cause X-linked Parkinsonism associated with Intellectual Disability, known as Waisman syndrome that has been mainly identified through exome sequencing in large Parkinson's disease cohorts. RAB39B mutation is very rare in familial PD and may not be a major cause of familial PD in the Chinese Han Population.

Product Categories/Family for anti-RAB39B antibody

Autophagy Pathway

References

Mignogna ML, et al. (2015) The intellectual disability protein rab39b selectively regulates glua2 trafficking to determine synaptic ampar composition. Nat Commun 6 6504.Ciammola A, et al. (2017) X-linked parkinsonism with intellectual disability caused by novel mutations and somatic mosaicism in rab39b gene. Parkinsonism Relat Disord 44 142-146.Cheng H, et al. (2002) Isolation and characterization of a human novel rab (rab39b) gene. Cytogenet Genome Res 97 (1-2): 72-75.