Immunohistochemistry (IHC)
(Anti-CUEDC2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.)
Rabbit anti-Human CUEDC2 Polyclonal Antibody | anti-CUEDC2 antibody
Anti-CUEDC2 Antibody (aa239-267) IHC-plus
Gene Names
CUEDC2; C10orf66; bA18I14.5
Reactivity
Human
Applications
Immunohistochemistry, Western Blot, Flow Cytometry, Functional Assay
Purity
Ammonium sulfate precipitation
Synonyms
CUEDC2; Polyclonal Antibody; Anti-CUEDC2 Antibody (aa239-267) IHC-plus; Rabbit Polyclonal to Human CUEDC2; Human CUEDC2; BA18I14.5; C10orf66; CUE domain containing 2; anti-CUEDC2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Human CUEDC2
Purity/Purification
Ammonium sulfate precipitation
Form/Format
PBS, 0.09% sodium azide
Sequence Length
287
Applicable Applications for anti-CUEDC2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes
Flow Cytometry (1:10 - 1:50)
IHC-P (1:75)
WB (1:1000)
IHC-P (1:75)
WB (1:1000)
Immunogen
CUEDC2 antibody was raised against kLH-conjugated synthetic peptide from C-terminal region of human CUEDC2.
Immunogen Description
KLH-conjugated synthetic peptide from C-terminal region of human CUEDC2.
Immunogen Type
Synthetic peptide
Antigen Modification
aa239-267
Target Species
Human
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
For long term storage store at -20 degree C.
Immunohistochemistry (IHC)
(Anti-CUEDC2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.)
Immunohistochemistry (IHC)
(Anti-CUEDC2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.)
Western Blot (WB)
(Western blot of CUEDC2 Antibody in Y79 cell line lysates (35 ug/lane). CUEDC2 (arrow) was detected using the purified antibody.)
Western Blot (WB)
(Western blot of CUEDC2 Antibody in Y79 cell line lysates (35 ug/lane). CUEDC2 (arrow) was detected using the purified antibody.)
Flow Cytometry (FC/FACS)
(Flow cytometric of HeLa cells using CUEDC2 Antibody (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(Flow cytometric of HeLa cells using CUEDC2 Antibody (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Related Product Information for anti-CUEDC2 antibody
CUEDC2 Antibody, BA18I14.5 Antibody, C10orf66 Antibody, CUE domain containing 2 Antibody Description: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
32,009 Da
NCBI Official Full Name
CUE domain-containing protein 2
NCBI Official Synonym Full Names
CUE domain containing 2
NCBI Official Symbol
CUEDC2
NCBI Official Synonym Symbols
C10orf66; bA18I14.5
NCBI Protein Information
CUE domain-containing protein 2
UniProt Protein Name
CUE domain-containing protein 2
Protein Family
UniProt Gene Name
CUEDC2
UniProt Synonym Gene Names
C10orf66
UniProt Entry Name
CUED2_HUMAN
Uniprot Description
CUEDC2: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression. Belongs to the CUEDC2 family.
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: cytoplasm; nuclear membrane; nucleoplasm
Molecular Function: protein binding
Research Articles on CUEDC2
Similar Products
Product Notes
The CUEDC2 cuedc2 (Catalog #AAA2400176) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CUEDC2 Antibody (aa239-267) IHC-plus reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CUEDC2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS). Flow Cytometry (1:10 - 1:50) IHC-P (1:75) WB (1:1000). Researchers should empirically determine the suitability of the CUEDC2 cuedc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CUEDC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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