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Immunohistochemistry (IHC) (Immunohistochemistry of PTPN5 in mouse brain tissue with PTPN5 antibody at 5 ug/ml.)

Rabbit anti-Mouse, Human PTPN5 / STEP Polyclonal Antibody | anti-PTPN5 / STEP antibody

Anti-PTPN5 / STEP Antibody (N-Terminus) IHC-plus

Gene Names
PTPN5; STEP; PTPSTEP
Reactivity
Mouse, Human
Applications
Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
Purity
Immunoaffinity purified
Synonyms
PTPN5 / STEP; Polyclonal Antibody; Anti-PTPN5 / STEP Antibody (N-Terminus) IHC-plus; Rabbit Polyclonal to Human PTPN5 / STEP; Human PTPN5 / STEP; Striatal enriched phosphatase; Striatum enriched phosphatase; PTPSTEP; anti-PTPN5 / STEP antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse, Human
Clonality
Polyclonal
Specificity
PTPN5 antibody is human and mouse reactive.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
565
Applicable Applications for anti-PTPN5 / STEP antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes
IF (20 ug/ml)
IHC-P (10 ug/ml)
WB (1 - 2 ug/ml)
Immunogen
PTPN5 / STEP antibody was raised against pTPN5 antibody was raised against an 18 amino acid peptide near the amino terminus of human PTPN5.
Immunogen Description
PTPN5 antibody was raised against an 18 amino acid peptide near the amino terminus of human PTPN5.
Immunogen Type
Synthetic peptide
Antigen Modification
N-Terminus
Target Species
Human
Preparation and Storage
Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles

Immunohistochemistry (IHC)

(Immunohistochemistry of PTPN5 in mouse brain tissue with PTPN5 antibody at 5 ug/ml.)

Immunohistochemistry (IHC) (Immunohistochemistry of PTPN5 in mouse brain tissue with PTPN5 antibody at 5 ug/ml.)

Immunohistochemistry (IHC)

(Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC) (Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC) (Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunofluorescence (IF)

(Immunofluorescence of PTPN5 in mouse brain tissue with PTPN5 antibody at 20 ug/ml.)

Immunofluorescence (IF) (Immunofluorescence of PTPN5 in mouse brain tissue with PTPN5 antibody at 20 ug/ml.)
Related Product Information for anti-PTPN5 / STEP antibody
PTPN5 Antibody, Striatal enriched phosphatase Antibody, Striatum enriched phosphatase Antibody, PTPSTEP Antibody, STEP Antibody Description: Striatum-enriched phosphatase, a R7 receptor protein tyrosine phosphatase, is a component of the N-methyl-D-aspartate receptor (NMDAR) complex and has been suggested affect the development and maturation of the striatal neurons. STEP has been shown to regulate the activity of Fyn and may be one mechanism by which Fyn activity is decreased within the postsynaptic densities (PSDs) of striatal neurons. Alternative splicing of STEP produces cytosolic, transmembrane, and truncated isoforms.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
60,961 Da
NCBI Official Full Name
Tyrosine-protein phosphatase non-receptor type 5
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 5
NCBI Official Symbol
PTPN5
NCBI Official Synonym Symbols
STEP; PTPSTEP
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 5
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 5
UniProt Gene Name
PTPN5
UniProt Synonym Gene Names
STEP
UniProt Entry Name
PTN5_HUMAN

Uniprot Description

STEP: a non-receptor protein-tyrosine phosphatase. STEP (striatum enriched phosphatase) Contains a single phosphatase catalytic domain located at the C-terminus. Two alternatively-spliced messages have been described.

Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: axon; cytosol; endoplasmic reticulum membrane; integral to membrane; perikaryon

Molecular Function: glutamate receptor binding; mitogen-activated protein kinase binding; phosphotyrosine binding; protein binding; protein tyrosine phosphatase activity

Biological Process: negative regulation of MAP kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of protein import into nucleus, translocation; positive regulation of receptor internalization; protein amino acid dephosphorylation; response to amphetamine; response to drug

Research Articles on PTPN5 / STEP

Similar Products

Product Notes

The PTPN5 / STEP ptpn5 (Catalog #AAA2400343) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-PTPN5 / STEP Antibody (N-Terminus) IHC-plus reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTPN5 / STEP can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA). IF (20 ug/ml) IHC-P (10 ug/ml) WB (1 - 2 ug/ml). Researchers should empirically determine the suitability of the PTPN5 / STEP ptpn5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTPN5 / STEP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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