Western Blot (WB)
(PTHB1 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PTHB1 antibody detected the PTHB1 protein (arrow).)
Rabbit anti-Human PTHB1 Polyclonal Antibody | anti-BBS9 antibody
PTHB1, CT (BBS9, PTHB1, Protein PTHB1, Bardet-Biedl syndrome 9 protein, Parathyroid hormone-responsive B1 gene protein)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(PTHB1 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PTHB1 antibody detected the PTHB1 protein (arrow).)
Western Blot (WB)
(PTHB1 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PTHB1 antibody detected the PTHB1 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
This gene is downregulated by parathyroid hormone in osteoblastic cells, and therefore, is thought to be involved in parathyroid hormone action in bones. The exact function of this gene has not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
BBS9: The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. A chromosomal aberration involving PTHB1 is found in Wilms tumor 5 (WT5). Translocation t(1;7)(q42;p15) with OBSCN. Defects in BBS9 are a cause of Bardet-Biedl syndrome type 9 (BBS9). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. 6 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 7p14
Cellular Component: pericentriolar material; cytosol; cilium
Molecular Function: protein binding
Biological Process: fat cell differentiation; protein transport; visual perception; organelle organization and biogenesis; response to stimulus; cilium biogenesis
Disease: Bardet-biedl Syndrome 9
Research Articles on BBS9
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Product Notes
The BBS9 bbs9 (Catalog #AAA6011762) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTHB1, CT (BBS9, PTHB1, Protein PTHB1, Bardet-Biedl syndrome 9 protein, Parathyroid hormone-responsive B1 gene protein) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTHB1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the BBS9 bbs9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTHB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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