Rabbit anti-Human PROKR1 Polyclonal Antibody | anti-PROKR1 antibody

PROKR1 Polyclonal Antibody

Cat. Num. AAA2559936

• Gene Names: PROKR1; ZAQ; PKR1; GPR73; PK-R1; GPR73a
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: PROKR1; Polyclonal Antibody; PROKR1 Polyclonal Antibody; EG-VEGF receptor; G protein coupled receptor 73; G protein coupled receptor ZAQ; G-protein coupled receptor 73; G-protein coupled receptor ZAQ; GPR73; GPR73a; PK R1; PK-R1; PKR1; Prokineticin receptor 1; Zaq; anti-PROKR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 1.14mg/mL (varies by lot)
• Sequence Length: 393

• Applicable Applications for anti-PROKR1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:40-1:200; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human PROKR1
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human tonsil tissue using PROKR1 Polyclonal Antibody at dilution of 1:40(×200))

Related Product Information for anti-PROKR1 antibody

This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage.PROKR1 (Prokineticin Receptor 1) is a Protein Coding gene. Diseases associated with PROKR1 include Ectopic Pregnancy. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is PROKR2.

Product Categories/Family for anti-PROKR1 antibody

Neuroscience; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 20373179
• NCBI GeneID: 10887
• NCBI Accession #: NP_620414.1
• NCBI GenBank Nucleotide #: NP_620414.1
• UniProt Accession #: Q8TCW9
• NCBI Official Full Name: prokineticin receptor 1
• NCBI Official Synonym Full Names: prokineticin receptor 1
• NCBI Official Symbol: PROKR1
• NCBI Official Synonym Symbols: ZAQ; PKR1; GPR73; PK-R1; GPR73a
• NCBI Protein Information: prokineticin receptor 1
• UniProt Protein Name: Prokineticin receptor 1
• Protein Family: Prokineticin receptor
• UniProt Gene Name: PROKR1
• UniProt Synonym Gene Names: GPR73; PKR1; PK-R1
• UniProt Entry Name: PKR1_HUMAN

NCBI Description

This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]

Uniprot Description

PROKR1: Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: neuropeptide Y receptor activity

Biological Process: neuropeptide signaling pathway; negative regulation of apoptosis