Rabbit anti-Human PRKCDBP/CAVIN3 Polyclonal Antibody | anti-PRKCDBP antibody

Anti-PRKCDBP/CAVIN3 Antibody (C-Terminus)

Cat. Num. AAA2400994

• Gene Names: CAVIN3; SRBC; HSRBC; PRKCDBP; cavin-3
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: PRKCDBP/CAVIN3; Polyclonal Antibody; Anti-PRKCDBP/CAVIN3 Antibody (C-Terminus); Goat Polyclonal to Human PRKCDBP/CAVIN3; PRKCDBP; CAVIN3; HSRBC; SRBC; Cavin-3; anti-PRKCDBP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: BLAST analysis suggests cross-reactivity with rat, human, and mouse based on 100% sequence homology. Cross-reactivity with Protein Kinase C delta-Binding Protein from other sources has not been determined.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 30% glycerol, sterile filtered
• Sequence Length: 261

• Applicable Applications for anti-PRKCDBP antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: ELISA: 1:10000; IHC-P: 5 ug/ml; WB: 1 ug/ml
• Immunogen: Protein Kinase C delta-Binding Protein affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminal region of human Protein Kinase C delta-Binding Protein.
• Conjugation: Unconjugated
• Epitope: C-Terminus
• Preparation and Storage: Short term storage: 4 degree C; Long term storage: aliquot and store at -20 degree C, avoid freeze thaw cycles.; Centrifuge product before removing cap. Only dilute immediately prior to use.

Immunohistochemistry (IHC)

(Anti-PRKCDBP/CAVIN3 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (WB)

(Anti-PRKCDBP/CAVIN3 antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-PRKCDBP antibody

Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulatesexpression and interaction of the core clock components PER1/2 and CRY1/2. Seems to have an immune potentiation function.

NCBI and Uniprot Product Information

• NCBI GI #: 47132587
• NCBI GeneID: 112464
• NCBI Accession #: NP_659477.2
• NCBI GenBank Nucleotide #: NM_145040.2
• UniProt Accession #: Q969G5
• Molecular Weight: 27,701 Da
• NCBI Official Full Name: caveolae-associated protein 3
• NCBI Official Synonym Full Names: caveolae associated protein 3
• NCBI Official Symbol: CAVIN3
• NCBI Official Synonym Symbols: SRBC; HSRBC; PRKCDBP; cavin-3
• NCBI Protein Information: caveolae-associated protein 3
• UniProt Protein Name: Caveolae-associated protein 3
• Protein Family: Protein kinase C delta-binding protein
• UniProt Gene Name: CAVIN3
• UniProt Synonym Gene Names: hSRBC

NCBI Description

The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

Uniprot Description

Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 ().