Goat PRKCDBP / CAVIN3 Polyclonal Antibody | anti-PRKCDBP antibody

Goat Polyclonal to Human PRKCDBP / CAVIN3

Cat. Num. AAA248060

• Gene Names: PRKCDBP; SRBC; HSRBC; CAVIN3; cavin-3
• Reactivity: Gibbon, Dog, Gorilla, Hamster, Horse, Human, Monkey, Pig; Predicted Reactivity: Mouse, Rat, Bat, Bovine, Rabbit (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: PRKCDBP / CAVIN3; Polyclonal Antibody; Goat Polyclonal to Human PRKCDBP / CAVIN3; Anti-PRKCDBP / CAVIN3 Antibody (Internal) IHC-plus; PRKCDBP; CAVIN3; HSRBC; SRBC; Cavin-3; Human PRKCDBP; anti-PRKCDBP antibody

• Host: Goat
• Reactivity: Gibbon, Dog, Gorilla, Hamster, Horse, Human, Monkey, Pig; Predicted Reactivity: Mouse, Rat, Bat, Bovine, Rabbit (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human PRKCDBP.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 261

• Applicable Applications for anti-PRKCDBP antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:32000), IHC-P (3.75 ug/ml), WB (0.1 - 1 ug/ml); Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Approx 38kDa band observed in Human Adipose and NIH3T3 lysates (calculated MW of 27.7kDa according to Human NP_659477.2 and 27.8kDa according to Mouse NP_082720.1). The observed...
• Target Species: Human
• Immunogen Description: Synthetic peptide C-RRTGLQKVQSLR from an internal region of human PRKCDBP (NP_659477.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Hamster, Panda, Dog, Horse, Pig, Opossum (100%).
• Immunogen Type: Synthetic peptide
• Immunogen: PRKCDBP / CAVIN3 antibody was raised against synthetic peptide C-RRTGLQKVQSLR from an internal region of human PRKCDBP (NP_659477.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Hamster, Panda, Dog, Horse, Pig, Opossum (100%); Mouse, Rat, Elephant, Bat, Bovine, Rabbit (92%); Drosophila (83%).
• Antigen Modification: Internal
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-PRKCDBP / CAVIN3 antibody IHC staining of human uterus, myometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Western Blot (WB)

(PRKCDBP antibody (0.1 ug/ml) staining of Human Adipose cell lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

NCBI and Uniprot Product Information

• NCBI GI #: 47132587
• NCBI GeneID: 112464
• NCBI Accession #: NP_659477.2
• NCBI GenBank Nucleotide #: NM_145040.2
• UniProt Accession #: Q969G5
• Molecular Weight: 27,701 Da
• NCBI Official Full Name: protein kinase C delta-binding protein
• NCBI Official Synonym Full Names: protein kinase C delta binding protein
• NCBI Official Symbol: PRKCDBP
• NCBI Official Synonym Symbols: SRBC; HSRBC; CAVIN3; cavin-3
• NCBI Protein Information: protein kinase C delta-binding protein
• UniProt Protein Name: Protein kinase C delta-binding protein
• Protein Family: Protein kinase C delta-binding protein
• UniProt Gene Name: PRKCDBP
• UniProt Synonym Gene Names: SRBC; hSRBC
• UniProt Entry Name: PRDBP_HUMAN

NCBI Description

The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

Uniprot Description

PRKCDBP: Seems to have an immune potentiation function. Belongs to the PTRF/SDPR family.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: protein complex; cytoplasm; caveola

Molecular Function: protein binding; protein kinase C binding

Biological Process: negative regulation of protein kinase B signaling cascade; circadian regulation of gene expression; cortical actin cytoskeleton organization and biogenesis