Rabbit CRLF2 Polyclonal Antibody | anti-CRLF2 antibody

CRLF2 Polyclonal Antibody

Cat. Num. AAA9129620

• Gene Names: CRLF2; CRL2; TSLPR; CRLF2Y
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purification
• Synonyms: CRLF2; Polyclonal Antibody; CRLF2 Polyclonal Antibody ; anti-CRLF2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Sequence Length: 259

• Applicable Applications for anti-CRLF2 antibody: Western Blot (WB)
• Application Notes: WB: 1:200 - 1:1000
• Immunogen: Recombinant protein of human CRLF2
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using CRLF2 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.)

Product Categories/Family for anti-CRLF2 antibody

Polyclonal

NCBI and Uniprot Product Information

• NCBI GI #: 589269166
• NCBI GeneID: 64109
• NCBI Accession #: NP_001012288.2
• NCBI GenBank Nucleotide #: NM_001012288.2
• UniProt Accession #: Q9HC73; Q5G7M1; Q9H5R3; J3QKD1
• Molecular Weight: Calculated MW: 42kDa; Molecular Weight: 371
• NCBI Official Full Name: cytokine receptor-like factor 2 isoform 2
• NCBI Official Synonym Full Names: cytokine receptor-like factor 2
• NCBI Official Symbol: CRLF2
• NCBI Official Synonym Symbols: CRL2; TSLPR; CRLF2Y
• NCBI Protein Information: cytokine receptor-like factor 2
• UniProt Protein Name: Cytokine receptor-like factor 2
• Protein Family: Cytokine receptor-like factor
• UniProt Gene Name: CRLF2
• UniProt Synonym Gene Names: CRL2; ILXR; TSLPR; TSLP receptor
• UniProt Entry Name: CRLF2_HUMAN

NCBI Description

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Description

CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.3; Yp11.3

Cellular Component: extracellular region; integral to membrane; plasma membrane