Rabbit anti-Human PPP2R1B Polyclonal Antibody | anti-PPP2R1B antibody

Anti-PPP2R1B Antibody, Rabbit Polyclonal

Cat. Num. AAA8104012

• Gene Names: PPP2R1B; PR65B; PP2A-Abeta
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: PPP2R1B; Polyclonal Antibody; Anti-PPP2R1B Antibody; Rabbit Polyclonal; PPP2R1B Antibody; Rabbit PAb; Antigen Affinity Purified; protein phosphatase 2 regulatory subunit A; beta; Anti-PP2A-Abeta Antibody; Anti-PR65B Antibody; anti-PPP2R1B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human PPP2R1B
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-PPP2R1B antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:200-1:1000
• Immunogen: A synthetic peptide corresponding to the C-terminus of the Human PPP2R1B
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human PPP2R1B, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human PPP2R1B in human testis with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-PPP2R1B antibody

The PPP2R1B gene, which encodes the beta isoform of the A subunit of the serine/threonine protein phosphatase 2A (PP2A), was identified as a putative human tumor suppressor gene. PPP2R1B is located on chromosome 11q22-24 which coincides with the site of frequent loss of heterozygosity (LOH) in ovarian cancer. Mutations of the PPP2R1B gene, which encodes the Abeta scaffolding subunit of serine/threonine protein phosphatase 2A (PP2A), have been identified in several types of cancer including lung and breast carcinoma. One of these mutations results in an alteration of glycine 90 to aspartic acid (G90D), which has been found in both tumor and genomic DNA, raising the possibility that it is associated with an increased risk for cancer.

NCBI and Uniprot Product Information

• NCBI GI #: 294774574
• NCBI GeneID: 5519
• NCBI Accession #: NP_001171033.1
• NCBI GenBank Nucleotide #: NM_001177562.1
• UniProt Accession #: P30154; O75620; Q8NHV8; B0YJ69; B4DGQ6; B4DWW5; F8W8G1
• Molecular Weight: 66,214 Da
• NCBI Official Full Name: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform d
• NCBI Official Synonym Full Names: protein phosphatase 2, regulatory subunit A, beta
• NCBI Official Symbol: PPP2R1B
• NCBI Official Synonym Symbols: PR65B; PP2A-Abeta
• NCBI Protein Information: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A, subunit A, R1-beta isoform; PP2A, subunit A, PR65-beta isoform; protein phosphatase 2, structural/regulatory subunit A, beta; protein phosphatase 2 (formerly 2A), regu
• UniProt Protein Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
• UniProt Gene Name: PPP2R1B
• UniProt Entry Name: 2AAB_HUMAN

NCBI Description

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Uniprot Description

PPP2R1B: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Belongs to the phosphatase 2A regulatory subunit A family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 11q23.2

Cellular Component: lipid raft

Molecular Function: protein binding

Disease: Lung Cancer