Rabbit anti-Human PPP1R9A Polyclonal Antibody | anti-PPP1R9A antibody

PPP1R9A, ID (PPP1R9A, KIAA1222, Neurabin-1, Neurabin-I, Neural tissue-specific F-actin-binding protein I, Protein phosphatase 1 regulatory subunit 9A) (FITC)

Cat. Num. AAA6336602

• Gene Names: PPP1R9A; NRB1; NRBI; Neurabin-I
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PPP1R9A; Polyclonal Antibody; ID (PPP1R9A; KIAA1222; Neurabin-1; Neurabin-I; Neural tissue-specific F-actin-binding protein I; Protein phosphatase 1 regulatory subunit 9A) (FITC); Protein phosphatase 1 regulatory subunit 9A; anti-PPP1R9A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Sequence Length: 1098

• Applicable Applications for anti-PPP1R9A antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PPP1R9A antibody is generated from rabbits immunized with a KLH conjugated synthetic between 454-484 amino acids selected from the Central region of human PPP1R9A.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PPP1R9A Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PPP1R9A antibody detected the PPP1R9A protein (arrow).)

Related Product Information for anti-PPP1R9A antibody

This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-PPP1R9A antibody

Antibodies; Actin Related Proteins

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Suarez-Gestal, M., et al. Arthritis Res. Ther. 12 (2), R72 (2010): Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Nakabayashi, K., et al. J. Med. Genet. 41(8):601-608(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 93204861
• NCBI GeneID: 55607
• NCBI Accession #: NP_060120.2
• NCBI GenBank Nucleotide #: NP_060120.2
• UniProt Accession #: Q9ULJ8
• NCBI Official Full Name: neurabin-1 isoform 4
• NCBI Official Synonym Full Names: protein phosphatase 1 regulatory subunit 9A
• NCBI Official Symbol: PPP1R9A
• NCBI Official Synonym Symbols: NRB1; NRBI; Neurabin-I
• NCBI Protein Information: neurabin-1
• UniProt Protein Name: Neurabin-1
• Protein Family: Neurabin
• UniProt Gene Name: PPP1R9A
• UniProt Synonym Gene Names: KIAA1222
• UniProt Entry Name: NEB1_HUMAN

NCBI Description

This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Description

neurabin 1: Binds to actin filaments (F-actin) and shows cross- linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1- alpha activity. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: cortical actin cytoskeleton; growth cone; dendritic spine; synapse; cell junction; filopodium

Molecular Function: actin filament binding; protein binding

Biological Process: calcium-mediated signaling; actin filament organization; neurite development