Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Human fetal muscle tissue Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes)
Rabbit PPARGC1A Polyclonal Antibody | anti-PPARGC1A antibody
PPARGC1A Antibody
Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Human fetal muscle tissue Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes)
Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Human fetal muscle tissue Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
Uniprot Description
PGC-1 alpha: a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to 'insulin response sequences' in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 4p15.1
Cellular Component: nucleoplasm; PML body; DNA-directed RNA polymerase II, core complex; cytosol; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; protein binding; androgen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; sequence-specific DNA binding; chromatin DNA binding; RNA binding; ubiquitin protein ligase binding; transcription coactivator activity; nucleotide binding; transcription factor binding
Biological Process: circadian rhythm; response to muscle activity; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; thermoregulation; positive regulation of gluconeogenesis; regulation of transcription, DNA-dependent; flavone metabolic process; protein complex assembly; circadian regulation of gene expression; negative regulation of neuron apoptosis; negative regulation of glycolysis; transcription initiation from RNA polymerase II promoter; mitochondrion organization and biogenesis; protein stabilization; RNA splicing; organelle organization and biogenesis; cellular respiration; androgen metabolic process; regulation of circadian rhythm; gluconeogenesis; response to starvation; response to leucine; digestion; positive regulation of fatty acid oxidation; androgen receptor signaling pathway; galactose metabolic process; brown fat cell differentiation; cell glucose homeostasis; positive regulation of transcription factor activity; positive regulation of histone acetylation; fatty acid oxidation; positive regulation of transcription from RNA polymerase II promoter; response to cold; mRNA processing
Research Articles on PPARGC1A
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Product Notes
The PPARGC1A ppargc1a (Catalog #AAA9413146) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PPARGC1A Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PPARGC1A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:200-1:1000. Researchers should empirically determine the suitability of the PPARGC1A ppargc1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPARGC1A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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