Rabbit anti-Human PNOC Polyclonal Antibody | anti-PNOC antibody

PNOC Antibody

Cat. Num. AAA9405557

• Gene Names: PNOC; OFQ; N/OFQ; PPNOC; ppN/OFQ
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: PNOC; Polyclonal Antibody; PNOC Antibody; PPNOC; anti-PNOC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total PNOC protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.7 mg/ml (varies by lot)
• Sequence Length: 112

• Applicable Applications for anti-PNOC antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human prepronociceptin
• Target Name: PNOC
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/40.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/40.)

Related Product Information for anti-PNOC antibody

Nociception, a pain response mechanism, occurs in response to stimuli that threaten the integrity of an organism. The first synapses produced as a result of the initiation of nociception are modulated by excitatory amino acids (glutamate and aspartate) and many peptides (substance P, CGRP, CCK, endogenous opioids). Nociceptin (also designated orphanin FQ) is a neuronal peptide that is similar to opioid peptides. Nociceptin activates KOR-3 (kappa-type opioid receptor, also designated ORL1), a G protein-coupled receptor. Although similar to dynorphin A, a kappa opioid peptide, nociceptin functions to make animals hyperreactive to nociceptive stimulations. Nociceptin is also involved in locomotor behavior and may be involved in the modulation of synaptic plasticity in learning and memory.

Product Categories/Family for anti-PNOC antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 545746382
• NCBI GeneID: 5368
• NCBI Accession #: NP_001271173.1
• NCBI GenBank Nucleotide #: NM_001284244.1
• UniProt Accession #: Q13519; Q6FH16; B7Z749
• Molecular Weight: 13,047 Da
• NCBI Official Full Name: prepronociceptin isoform 2
• NCBI Official Synonym Full Names: prepronociceptin
• NCBI Official Symbol: PNOC
• NCBI Official Synonym Symbols: OFQ; N/OFQ; PPNOC; ppN/OFQ
• NCBI Protein Information: prepronociceptin
• UniProt Protein Name: Prepronociceptin
• Protein Family: Prepronociceptin
• UniProt Gene Name: PNOC
• UniProt Synonym Gene Names: OFQ
• UniProt Entry Name: PNOC_HUMAN

NCBI Description

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]

Uniprot Description

PNOC: Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Belongs to the opioid neuropeptide precursor family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: extracellular region

Molecular Function: neuropeptide hormone activity; protein binding; opioid peptide activity

Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; signal transduction