Rabbit Calcium Sensing Receptor Polyclonal Antibody | anti-CASR antibody

Anti-Calcium Sensing Receptor (Extracellular) Antibody

Cat. Num. AAA4157629

• Gene Names: CASR; CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; hCasR; GPRC2A; HYPOC1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: Calcium Sensing Receptor; Polyclonal Antibody; Anti-Calcium Sensing Receptor (Extracellular) Antibody; anti-CASR antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 295

• Applicable Applications for anti-CASR antibody: Western Blot (WB)
• Immunogen: Peptide (C)DDYG RPGIE KFREE, corresponding to amino acid residues 216-229 of human CaSR (Accession P41180).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-CASR antibody

The Calcium-Sensing Receptor (CaSR) is a member of subfamily C of the G-protein-coupled receptor (GPCR) superfamily. As its primary role, the CaSR is a key player in calcium homeostasis and is expressed in tissues involved in calcium metabolism, such as parathyroid cells and kidney.1, 2 The expression of CaSR was also described in other cell types and tissues, such as neurons, keratinocytes, and pancreas. However, the role of CaSR in these cells remains to be established.1, 2 Following the identification of functional vitamin D response elements in the CaSR gene, it was suggested that vitamin D might regulate the expression of CaSR.3 CaSR activation is followed by a rapid, transient increase in the cytosolic calcium concentration, resulting from mobilization of calcium from thapsigargin-sensitive intracellular stores, as well as an increased calcium influx through voltage-insensitive calcium channels located at the cell membrane.4 CaSR regulates cellular processes such as proliferation, apoptosis, and differentiation under both normal and pathologic conditions.5 Recent studies demonstrated the expression in human colon epithelium of CaSR, which regulates proliferation and differentiation. In colon carcinomas, lower levels of expression were found in compared to normal colon tissue. The Anti-CaSR (extracellular) antibody can be used in Western blotting analyses and recognizes human, rat, and mouse CaSR samples.

NCBI and Uniprot Product Information

• NCBI GI #: 86559371
• NCBI GeneID: 846
• NCBI Official Full Name: calcium sensing receptor, partial
• NCBI Official Synonym Full Names: calcium sensing receptor
• NCBI Official Symbol: CASR
• NCBI Official Synonym Symbols: CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; hCasR; GPRC2A; HYPOC1
• NCBI Protein Information: extracellular calcium-sensing receptor
• Protein Family: Calcium sensing receptor

NCBI Description

The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]