Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Rat Platelet Derived Growth Factor BB (PDGFBB) Polyclonal Antibody | anti-PDGFBB antibody
Polyclonal Antibody to Platelet Derived Growth Factor BB (PDGFBB)
MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF-CYLRLV SAEGDPIPEE LYEMLSDHSI RSFDDLQRLL HRDSVDEDGA ELDLNMTRAH SGVESESSSR GRRSLGSLAA AEPAVIAECK TRTEVFQISR NLIDRTNANF LVWPPCVEVQ RCSGCCNNRN VQCRASQVQM RPVQVRKIEI VRKKPVFKKA TVTLEDHLAC KCETVVTPRP VTRSPGTSRE HRAKTPQTRV TVRTVRIRRP PKGKHRKFKH THDKK
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded smooth muscle tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded smooth muscle tissue))
NCBI and Uniprot Product Information
NCBI Description
may play a role in carotid artery smooth muscle cell proliferation and neointimal formation in response to balloon catheter injury [RGD, Feb 2006]
Uniprot Description
PDGFB: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB. Belongs to the PDGF/VEGF growth factor family.
Protein type: Motility/polarity/chemotaxis; Oncoprotein; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7q34
Cellular Component: basolateral plasma membrane; cell soma; cell surface; cytoplasm; dendrite; extracellular matrix; extracellular space; intracellular; membrane
Molecular Function: chemoattractant activity; collagen binding; growth factor activity; identical protein binding; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein heterodimerization activity; protein homodimerization activity; receptor binding; superoxide-generating NADPH oxidase activator activity
Biological Process: actin cytoskeleton organization; activation of protein kinase activity; activation of protein kinase B activity; blood coagulation; blood vessel development; blood vessel morphogenesis; cell growth; cell projection assembly; DNA replication; embryonic placenta development; eye photoreceptor cell development; glial cell development; heart development; hemopoiesis; male gonad development; monocyte chemotaxis; negative regulation of cell migration; negative regulation of phosphatidylinositol biosynthetic process; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; neuron remodeling; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of collagen biosynthetic process; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA replication; positive regulation of endothelial cell proliferation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; positive regulation of glomerular filtration; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of mitotic cell cycle, embryonic; positive regulation of mitotic nuclear division; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-templated; protein amino acid phosphorylation; regulation of cell proliferation; regulation of peptidyl-tyrosine phosphorylation; response to axon injury; response to drug; response to estradiol; response to estrogen; response to hypoxia; response to insulin stimulus; response to organic cyclic compound; response to organic substance; response to wounding; retina development in camera-type eye; substrate-bound cell migration; synaptogenesis; wound healing
Research Articles on PDGFBB
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Product Notes
The PDGFBB pdgfb (Catalog #AAA2006010) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Platelet Derived Growth Factor BB (PDGFBB) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Platelet Derived Growth Factor BB (PDGFBB) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the PDGFBB pdgfb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF -CYLRLV SAEGDPIPEE LYEMLSDHSI RSFDDLQRLL HRDSVDEDGA ELDLNMTRAH SGVESESSSR GRRSLGSLAA AEPAVIAECK TRTEVFQISR NLIDRTNANF LVWPPCVEVQ RCSGCCNNRN VQCRASQVQM RPVQVRKIEI VRKKPVFKKA TVTLEDHLAC KCETVVTPRP VTRSPGTSRE HRAKTPQTRV TVRTVRIRRP PKGKHRKFKH THDKK. It is sometimes possible for the material contained within the vial of "Platelet Derived Growth Factor BB (PDGFBB), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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