Intercellular Adhesion Molecule 5 (ICAM5) Recombinant Protein | ICAM5 recombinant protein

Recombinant Intercellular Adhesion Molecule 5 (ICAM5)

Cat. Num. AAA2012190

• Gene Names: ICAM5; TLN; TLCN
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Intercellular Adhesion Molecule 5 (ICAM5); Recombinant Intercellular Adhesion Molecule 5 (ICAM5); ICAM5 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below.; MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF- RL DDSDCPRSWT WPEGPEQTLR CEARGNPEPS VHCARSDGGA VLALGLLGPV TRALSGTYRC KAANDQGEAV KDVTLTVEYA PALDSVGCPE RITWLEGTEA SLSCVAHGVP PPDVICVRSG ELGAVIEGLLRVAREHAGTY RCEATNPRGS AAKNVAVTVE YGPRFEEPSC PSNWTWVEGS GRLFSCEVDG KPQPSVKCVG SGGATEGVLL PLAPPDPSPR APRIPRVLAP GIYVCNATNRHGSVAKTVVV SAESPPEMDE STCP
• Sequence Length: 924

• Applicable Applications for ICAM5 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Homo sapiens (Human)
• Expression System: Prokaryotic expression
• Residues: Arg409~Pro674 (Accession # Q9UMF0) with two N-terminal Tags, His-tag and GST-tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

Sequence Information

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 189571583
• NCBI GeneID: 7087
• NCBI Accession #: NP_003250.3
• NCBI GenBank Nucleotide #: NM_003259.3
• UniProt Accession #: Q9UMF0; Q9Y6F3
• Molecular Weight: 60.0kDa
• NCBI Official Full Name: intercellular adhesion molecule 5
• NCBI Official Synonym Full Names: intercellular adhesion molecule 5, telencephalin
• NCBI Official Symbol: ICAM5
• NCBI Official Synonym Symbols: TLN; TLCN
• NCBI Protein Information: intercellular adhesion molecule 5; ICAM-5; telencephalin
• UniProt Protein Name: Intercellular adhesion molecule 5
• Protein Family: Intercellular adhesion molecule
• UniProt Gene Name: ICAM5
• UniProt Synonym Gene Names: TLCN; TLN; ICAM-5
• UniProt Entry Name: ICAM5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]

Uniprot Description

ICAM5: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Belongs to the immunoglobulin superfamily. ICAM family.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: integrin binding; protein binding

Biological Process: cell-cell adhesion; cell adhesion; phagocytosis