Rabbit anti-Human Plasminogen activator inhibitor type-1 Polyclonal Antibody | anti-PAI-1 antibody
Plasminogen activator inhibitor type-1: Human, Rabbit polyclonal (Antibody)
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Rabbit IgG was purified by protein-G
Synonyms
Plasminogen activator inhibitor type-1; Polyclonal Antibody; Plasminogen activator inhibitor type-1: Human; Rabbit polyclonal (Antibody); Plasminogen Activator Inhibitor-1 (PAI-1); Polyclonal Antibody against: Human Plasminogen activator inhibitor type-1; anti-PAI-1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
The antibody detects human PAI-1.
Purity/Purification
Rabbit IgG was purified by protein-G
Form/Format
Solution in PBS
Sequence Length
9
Applicable Applications for anti-PAI-1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
ELISA: This antibody can be used in ELISA with the appropriate secondary reagents to detecthuman PAI-1.
Immunogen
Recombinant full-length human PAI-1 expressed in E Coli
Preparation and Storage
Store at -20 degree C. For long-term storage, aliquot and freeze at -70 degree C. Avoid repeated freeze/defrost cycles.
Related Product Information for anti-PAI-1 antibody
Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activator, playing a major role in fibrinolysis. PAI-1 is mainly produced by the endothelium, but is also secreted by other tissue types, such as adipose tissue. It is normally present at low levels in plasma and tissue, but its expression and release increased in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome. PAI-1 is also involved in the pathophysiology of renal, pulmonary, cardiovascular, and metabolic diseases. Elevated local or systemic PAI-1 can also exacerbate such pathologic conditions.
References
1. Plasminogen activator inhibitor-1 (PAI-1): a key factor linking fibrinolysis and age-related subclinical and clinical conditions. Cesari M, Pahor M, Incalzi RA. Cardiovasc Ther. 2010 28(5):e72-91.
2. The plasminogen activation system: new targets in lung inflammation and remodeling. Schuliga M, Westall G, Xia Y, Stewart AG. Curr Opin Pharmacol. 2013 13(3):386-93
2. The plasminogen activation system: new targets in lung inflammation and remodeling. Schuliga M, Westall G, Xia Y, Stewart AG. Curr Opin Pharmacol. 2013 13(3):386-93
NCBI and Uniprot Product Information
NCBI GI #
NCBI Official Full Name
plasminogen activator inhibitor type 1, partial
Similar Products
Product Notes
The PAI-1 (Catalog #AAA398020) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Plasminogen activator inhibitor type-1: Human, Rabbit polyclonal (Antibody) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Plasminogen activator inhibitor type-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). ELISA: This antibody can be used in ELISA with the appropriate secondary reagents to detecthuman PAI-1. Researchers should empirically determine the suitability of the PAI-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Plasminogen activator inhibitor type-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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