Rabbit anti-Human PKD2L1 Polyclonal Antibody | anti-PKD2L1 antibody

PKD2L1, NT (PKD2L1, PKD2L, PKDL, Polycystic kidney disease 2-like 1 protein, Polycystin-2 homolog, Polycystin-2L1, Polycystin-L, Polycystin-L1) (FITC)

Cat. Num. AAA6334380

• Gene Names: PKD2L1; PCL; PKDL; PKD2L; TRPP3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PKD2L1; Polyclonal Antibody; NT (PKD2L1; PKD2L; PKDL; Polycystic kidney disease 2-like 1 protein; Polycystin-2 homolog; Polycystin-2L1; Polycystin-L; Polycystin-L1) (FITC); Polycystin-L1; anti-PKD2L1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-PKD2L1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PKD2L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from the N-terminal region of human PKD2L1.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PKD2L1 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PKD2L1 antibody detected the PKD2L1 protein (arrow).)

Related Product Information for anti-PKD2L1 antibody

PKD2L1 is a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N-and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.

Product Categories/Family for anti-PKD2L1 antibody

Antibodies; Disease Markers

References

Molland, K.L., et al. Biochem. J. 429(1):171-183(2010). Kawaguchi, H., et al. J. Biol. Chem. 285(23):17277-17281(2010). Li, Q., et al. J. Neurochem. 103(6):2391-2400(2007). Geng, L., et al. J. Cell. Sci. 119 (PT 7), 1383-1395 (2006): Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 33598944
• NCBI GeneID: 9033
• NCBI Accession #: NP_057196.2
• NCBI GenBank Nucleotide #: NM_016112.2
• UniProt Accession #: Q9P0L9; O75972; Q5W039; Q9UP35; Q9UPA2
• Molecular Weight: 88,472 Da
• NCBI Official Full Name: polycystic kidney disease 2-like 1 protein isoform 1
• NCBI Official Synonym Full Names: polycystic kidney disease 2-like 1
• NCBI Official Symbol: PKD2L1
• NCBI Official Synonym Symbols: PCL; PKDL; PKD2L; TRPP3
• NCBI Protein Information: polycystic kidney disease 2-like 1 protein; polycystin-L; polycystin-L1; polycystin-2L1; polycystin-2 homolog; transient receptor potential cation channel, subfamily P, member 3
• UniProt Protein Name: Polycystic kidney disease 2-like 1 protein
• Protein Family: Polycystic kidney disease 2-like 1 protein
• UniProt Gene Name: PKD2L1
• UniProt Synonym Gene Names: PKD2L; PKDL; TRPP3

NCBI Description

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

PKD2L1: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling. Belongs to the polycystin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q24.31

Cellular Component: cell surface; endoplasmic reticulum; integral component of membrane; intracellular membrane-bound organelle; membrane; plasma membrane; receptor complex

Molecular Function: alpha-actinin binding; calcium activated cation channel activity; calcium channel activity; calcium ion binding; calcium-activated potassium channel activity; cation channel activity; cation transmembrane transporter activity; cytoskeletal protein binding; identical protein binding; muscle alpha-actinin binding; protein binding; sodium channel activity; sour taste receptor activity

Biological Process: cation transport; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; sensory perception of sour taste; smoothened signaling pathway