Testing Data
(Image: E18 hippocampal neurons grown for four days and stained in the green channel with monoclonal antibody to Growth Associated Protein 43 (GAP43) an abundant protein of neuronal membranes especially concentrated in axonal membranes and growth cones. GAP43 is heavily palmitoylated in the Golgi, so this antibody can be used to localize the neuronal Golgi complex. Blue stain is DAPI and reveals cell nuclei of these neuronal cells. Protocol on data-sheet.)
GAP43 Antibody | anti-GAP43 antibody
GAP43, Monoclonal Antibody, Mouse
Testing Data
(Image: E18 hippocampal neurons grown for four days and stained in the green channel with monoclonal antibody to Growth Associated Protein 43 (GAP43) an abundant protein of neuronal membranes especially concentrated in axonal membranes and growth cones. GAP43 is heavily palmitoylated in the Golgi, so this antibody can be used to localize the neuronal Golgi complex. Blue stain is DAPI and reveals cell nuclei of these neuronal cells. Protocol on data-sheet.)
Testing Data
(Image: E18 hippocampal neurons grown for four days and stained in the green channel with monoclonal antibody to Growth Associated Protein 43 (GAP43) an abundant protein of neuronal membranes especially concentrated in axonal membranes and growth cones. GAP43 is heavily palmitoylated in the Golgi, so this antibody can be used to localize the neuronal Golgi complex. Blue stain is DAPI and reveals cell nuclei of these neuronal cells. Protocol on data-sheet.)
Testing Data
(Image: Western blot of whole rat spinal cord lysates probed with mouse monoclonal antibody to GAP43 in lane 16 and another similar antibody in lane 17. Dots in middle of strips indicate position of 50kDa and 37kDa protein bands. Note that the strong single band running at about 43kDa corresponds to GAP43.)
Testing Data
(Image: Western blot of whole rat spinal cord lysates probed with mouse monoclonal antibody to GAP43 in lane 16 and another similar antibody in lane 17. Dots in middle of strips indicate position of 50kDa and 37kDa protein bands. Note that the strong single band running at about 43kDa corresponds to GAP43.)
NCBI and Uniprot Product Information
Uniprot Description
GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface
Cellular Component: filopodium membrane; axon; postsynaptic density; cell junction
Molecular Function: calmodulin binding
Biological Process: cell fate commitment; glial cell differentiation; regulation of growth; axon choice point recognition; regulation of filopodium formation
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Product Notes
The GAP43 gap43 (Catalog #AAA555041) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The GAP43, Monoclonal Antibody, Mouse reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GAP43 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB). Researchers should empirically determine the suitability of the GAP43 gap43 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GAP43, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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