Rabbit anti-Human PITX2 Polyclonal Antibody | anti-PITX2 antibody

PITX2, NT (PITX2, ARP1, RGS, RIEG, RIEG1, Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin)

Cat. Num. AAA6001254

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PITX2; Polyclonal Antibody; NT (PITX2; ARP1; RGS; RIEG; RIEG1; Pituitary homeobox 2; ALL1-responsive protein ARP1; Homeobox protein PITX2; Paired-like homeodomain transcription factor 2; RIEG bicoid-related homeobox transcription factor; Solurshin); Anti -PITX2; anti-PITX2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-PITX2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: PITX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-71 amino acids from the N-terminal region of human PITX2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PITX2 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PITX2 antibody detected the PITX2 protein (arrow).)

Related Product Information for anti-PITX2 antibody

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Product Categories/Family for anti-PITX2 antibody

Antibodies; Abs to Transcription Factors; Zinc; Ring; Homeobox

NCBI and Uniprot Product Information

• NCBI GI #: 45384358
• NCBI GeneID: 395862
• NCBI Accession #: NP_990341.1
• NCBI GenBank Nucleotide #: NM_205010.1
• UniProt Accession #: O93385; O73854; Q9PWE0
• Molecular Weight: 36,558 Da
• NCBI Official Full Name: pituitary homeobox 2
• NCBI Official Synonym Full Names: paired-like homeodomain 2
• NCBI Official Symbol: PITX2
• NCBI Protein Information: pituitary homeobox 2; cPITX2; homeobox protein PITX2; transcription factor Pitx2; paired-like homeodomain transcription factor 2
• UniProt Protein Name: Pituitary homeobox 2
• Protein Family: Pituitary homeobox
• UniProt Gene Name: PITX2
• UniProt Synonym Gene Names: PTX2; cPITX2
• UniProt Entry Name: PITX2_CHICK

Uniprot Description

Function: May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis.

Subcellular location: Nucleus.

Sequence similarities: Belongs to the paired homeobox family. Bicoid subfamily.Contains 1 homeobox DNA-binding domain.