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Immunohistochemistry (IHC) (Anti-PITPNM3 / NIR1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Goat PITPNM3 / NIR1 Polyclonal Antibody | anti-PITPNM3 antibody

Goat Polyclonal to Human PITPNM3 / NIR1

Gene Names
PITPNM3; NIR1; ACKR6; CORD5; RDGBA3; PITPNM3
Reactivity
Gorilla, Horse, Human, Mouse, Pig
Predicted Reactivity: Rat, Dog (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry, ELISA
Purity
Immunoaffinity Purified
Synonyms
PITPNM3 / NIR1; Polyclonal Antibody; Goat Polyclonal to Human PITPNM3 / NIR1; Anti-PITPNM3 / NIR1 Antibody (C-Terminus) IHC-plus; PITPNM3; CORD5; NIR-1; NIR1; PITPnm 3; Retinal degeneration B alpha 3; PITPNM family member 3; RDGBA3; Human PITPNM3; anti-PITPNM3 antibody
Ordering
For Research Use Only!
Host
Goat
Reactivity
Gorilla, Horse, Human, Mouse, Pig
Predicted Reactivity: Rat, Dog (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human PITPNM3 / NIR1.
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
974
Applicable Applications for anti-PITPNM3 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes
ELISA (1:16000), IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Target Species
Human
Immunogen Description
Synthetic peptide C-SWARGPPKFESVP from the C-terminus of human PITPNM3 / NIR1 (NP_112497.2; NP_001159438.1). Percent identity by BLAST analysis: Human, Gorilla, Mouse, Horse, Pig (100%); Rat, Dog (92%).
Immunogen Type
Synthetic peptide
Immunogen
PITPNM3 / NIR1 antibody was raised against synthetic peptide C-SWARGPPKFESVP from the C-terminus of human PITPNM3 / NIR1 (NP_112497.2; NP_001159438.1). Percent identity by BLAST analysis: Human, Gorilla, Mouse, Horse, Pig (100%); Rat, Dog (92%).
Antigen Modification
C-Terminus
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-PITPNM3 / NIR1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC) (Anti-PITPNM3 / NIR1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
102,710 Da
NCBI Official Full Name
membrane-associated phosphatidylinositol transfer protein 3 isoform 1
NCBI Official Synonym Full Names
PITPNM family member 3
NCBI Official Symbol
PITPNM3
NCBI Official Synonym Symbols
NIR1; ACKR6; CORD5; RDGBA3; PITPNM3
NCBI Protein Information
membrane-associated phosphatidylinositol transfer protein 3; NIR-1; PITPnm 3; cone rod dystrophy 5; atypical chemokine receptor 6; retinal degeneration B alpha 3; PYK2 N-terminal domain-interacting receptor 1; phosphatidylinositol transfer protein, membrane-associated 3
UniProt Protein Name
Membrane-associated phosphatidylinositol transfer protein 3
UniProt Gene Name
PITPNM3
UniProt Synonym Gene Names
NIR1; PITPnm 3; NIR-1
UniProt Entry Name
PITM3_HUMAN

NCBI Description

This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Description

PITPNM3: transfers phosphatidylinositol and phosphatidylcholine between membranes. Binds calcium ions. Interacts with Pyk2 via its C-terminus. Two splice-variant isoforms have been described.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: integral to membrane; endomembrane system; intracellular

Molecular Function: protein binding; phosphatidylinositol transporter activity; calcium ion binding; receptor tyrosine kinase binding; lipid binding

Biological Process: phospholipid transport; phosphatidylinositol metabolic process

Disease: Cone-rod Dystrophy 5

Research Articles on PITPNM3

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Product Notes

The PITPNM3 pitpnm3 (Catalog #AAA241961) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat Polyclonal to Human PITPNM3 / NIR1 reacts with Gorilla, Horse, Human, Mouse, Pig Predicted Reactivity: Rat, Dog (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's PITPNM3 / NIR1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), ELISA (EIA). ELISA (1:16000), IHC-P (5 ug/ml) Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.. Researchers should empirically determine the suitability of the PITPNM3 pitpnm3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PITPNM3 / NIR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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