Rabbit anti-Human PHLDA1 Polyclonal Antibody | anti-PHLDA1 antibody

PHLDA1, NT (PHLDA1, PHRIP, TDAG51, Pleckstrin homology-like domain family A member 1, Apoptosis-associated nuclear protein, Proline-and glutamine-rich protein, Proline-and histidine-rich protein, T-cell death-associated gene 51 protein) (PE)

Cat. Num. AAA6333430

• Gene Names: PHLDA1; PHRIP; TDAG51; DT1P1B11
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PHLDA1; Polyclonal Antibody; NT (PHLDA1; PHRIP; TDAG51; Pleckstrin homology-like domain family A member 1; Apoptosis-associated nuclear protein; Proline-and glutamine-rich protein; Proline-and histidine-rich protein; T-cell death-associated gene 51 protein) (PE); T-cell death-associated gene 51 protein; anti-PHLDA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-PHLDA1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PHLDA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 22-49 amino acids selected from the N-terminal region of human PHLDA1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(PHLDA1 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the PHLDA1 antibody detected the PHLDA1 protein (arrow).)

Related Product Information for anti-PHLDA1 antibody

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.

Product Categories/Family for anti-PHLDA1 antibody

Antibodies; Pleckstrin Homology Proteins

References

Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009). Marchiori, A.C., et al. Braz. J. Med. Biol. Res. 41(7):579-582(2008). Nagai, M.A., et al. Breast Cancer Res. Treat. 106(1):49-56(2007). Xi, Z.Q., et al. Neurosci. Lett. 425(1):53-58(2007). Meier-Noorden, M., et al. Gene 338(2):197-207(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 83977459
• NCBI GeneID: 22822
• NCBI Accession #: NP_031376.3
• NCBI GenBank Nucleotide #: NM_007350.3
• UniProt Accession #: Q8WV24; Q15184; Q2TAN2; Q9NZ17; A1A4G9
• Molecular Weight: 45,016 Da
• NCBI Official Full Name: pleckstrin homology-like domain family A member 1
• NCBI Official Synonym Full Names: pleckstrin homology-like domain, family A, member 1
• NCBI Official Symbol: PHLDA1
• NCBI Official Synonym Symbols: PHRIP; TDAG51; DT1P1B11
• NCBI Protein Information: pleckstrin homology-like domain family A member 1; PQR protein; PQ-rich protein; proline-histidine rich protein; proline- and glutamine-rich protein; proline- and histidine-rich protein; apoptosis-associated nuclear protein; T-cell death-associated gene 5
• UniProt Protein Name: Pleckstrin homology-like domain family A member 1
• Protein Family: Pleckstrin homology-like domain family
• UniProt Gene Name: PHLDA1
• UniProt Synonym Gene Names: PHRIP; TDAG51; PQ-rich protein; PQR protein
• UniProt Entry Name: PHLA1_HUMAN

NCBI Description

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]

Uniprot Description

PHLDA1: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.

Protein type: Nucleolus; Apoptosis

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: nucleoplasm; cytoplasmic vesicle membrane; nucleolus; plasma membrane

Molecular Function: protein binding

Biological Process: apoptosis; positive regulation of apoptosis; forebrain neuron differentiation; FasL biosynthetic process