Western Blot (WB)
(Western blot analysis of PHKG2 expression in HepG2 (A), Jurkat (B), mouse brain (C), rat liver (D) whole cell lysates.)
Rabbit anti-Human PHKG2 Polyclonal Antibody | anti-PHKG2 antibody
Anti-PHKG2 Antibody
Western Blot (WB)
(Western blot analysis of PHKG2 expression in HepG2 (A), Jurkat (B), mouse brain (C), rat liver (D) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of PHKG2 expression in HepG2 (A), Jurkat (B), mouse brain (C), rat liver (D) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Uniprot Description
PHKG2: a Ca(2 )/calmodulin-dependent protein kinase of the PHK family. Phosphorylase kinase is a polymer of 16 chains, four each of alpha, beta, gamma, and delta. Alpha and beta are regulatory chains, gamma is the catalytic chain, and delta is calmodulin. This isozyme may regulate glycogeneolysis in the testis.
Protein type: Kinase, protein; Protein kinase, CAMK; EC 2.7.11.19; Protein kinase, Ser/Thr (non-receptor); CAMK group; PHK family
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytosol; phosphorylase kinase complex
Molecular Function: ATP binding; calmodulin binding; enzyme binding; phosphorylase kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity
Biological Process: generation of precursor metabolites and energy; glycogen biosynthetic process; glycogen catabolic process; glycogen metabolic process; positive regulation of glycogen catabolic process; protein amino acid phosphorylation
Disease: Glycogen Storage Disease Ixc
Research Articles on PHKG2
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Product Notes
The PHKG2 phkg2 (Catalog #AAA8245340) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-PHKG2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PHKG2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1/500 - 1/2000. Researchers should empirically determine the suitability of the PHKG2 phkg2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PHKG2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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