Rabbit PHKG2 Polyclonal Antibody | anti-PHKG2 antibody

PHKG2 Polyclonal Antibody

Cat. Num. AAA2521645

• Gene Names: PHKG2; GSD9C
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: PHKG2; Polyclonal Antibody; PHKG2 Polyclonal Antibody; GSD9C; anti-PHKG2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.9mg/mL (varies by lot)
• Sequence Length: 374

• Applicable Applications for anti-PHKG2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human PHKG2
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain tissue using PHKG2 Polyclonal Antibody at dilution 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PHKG2 Polyclonal Antibody at dilution 1:30)

Related Product Information for anti-PHKG2 antibody

Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes.

NCBI and Uniprot Product Information

• NCBI GI #: 289063422
• NCBI GeneID: 5261
• NCBI Accession #: NP_001165903.1
• NCBI GenBank Nucleotide #: NM_001172432.1
• Molecular Weight: 43,158 Da
• NCBI Official Full Name: phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform 2
• NCBI Official Synonym Full Names: phosphorylase kinase, gamma 2 (testis)
• NCBI Official Symbol: PHKG2
• NCBI Official Synonym Symbols: GSD9C
• NCBI Protein Information: phosphorylase b kinase gamma catalytic chain, liver/testis isoform; PHK-gamma-LT; PHK-gamma-T; PSK-C3; Phosphorylase kinase, gamma 2 (testis/liver); phosphorylase b kinase gamma catalytic chain, testis/liver isoform; phosphorylase kinase subunit gamma-2; serine/threonine-protein kinase PHKG2
• UniProt Protein Name: Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
• Protein Family: Phosphorylase b kinase
• UniProt Gene Name: PHKG2
• UniProt Synonym Gene Names: PHK-gamma-LT; PHK-gamma-T
• UniProt Entry Name: PHKG2_HUMAN

NCBI Description

Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Uniprot Description

PHKG2: a Ca(2 )/calmodulin-dependent protein kinase of the PHK family. Phosphorylase kinase is a polymer of 16 chains, four each of alpha, beta, gamma, and delta. Alpha and beta are regulatory chains, gamma is the catalytic chain, and delta is calmodulin. This isozyme may regulate glycogeneolysis in the testis.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.19; Kinase, protein; Protein kinase, CAMK; CAMK group; PHK family

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: phosphorylase kinase complex; cytosol

Molecular Function: calmodulin binding; phosphorylase kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; ATP binding

Biological Process: glycogen metabolic process; generation of precursor metabolites and energy; glycogen biosynthetic process; glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis; positive regulation of glycogen catabolic process; protein amino acid phosphorylation

Disease: Glycogen Storage Disease Ixc