Rabbit anti-Human, Mouse PDZD3 Polyclonal Antibody | anti-PDZD3 antibody

PDZD3 Antibody

Cat. Num. AAA9629730

• Gene Names: PDZD3; IKEPP; PDZK2; NHERF4
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: PDZD3; Polyclonal Antibody; PDZD3 Antibody; IKEPP; Intestinal and kidney enriched PDZ protein; Intestinal and kidney-enriched PDZ protein; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Na/Pi cotransporter C terminal associated protein 2; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; NHERF-4; NHERF4; NHRF4_HUMAN; PDZ domain containing 2; PDZ domain containing 3; PDZ domain containing protein 2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; PDZD 3; Pdzd3; PDZK2; Protein DLNB27; Sodium-hydrogen exchanger regulatory factor 4; anti-PDZD3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: PDZD3 Antibody detects endogenous levels of total PDZD3.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-PDZD3 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Subunit Structure: Interacts with the C-terminal region of GUCY2C. Interacts with the C-terminal region SLC9A3 and the interactions decrease in response to elevated calcium ion levels. Interacts with the C-terminal region of SLC34A1 (By similarity). Interacts with USP2 isoform 4.
• Tissue Specificity: Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.
• Function: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.
• Note: Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-PDZD3 antibody

Cell membrane; Peripheral membrane protein; Cytoplasm; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 20809633
• NCBI GeneID: 79849
• UniProt Accession #: Q86UT5; Q8N6R4; Q8NAW7; Q8NEX7; Q9H5Z3
• Molecular Weight: 24,105 Da
• NCBI Official Full Name: Homo sapiens PDZ domain containing 3, mRNA
• NCBI Official Synonym Full Names: PDZ domain containing 3
• NCBI Official Symbol: PDZD3
• NCBI Official Synonym Symbols: IKEPP; PDZK2; NHERF4
• NCBI Protein Information: Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; NHERF-4; PDZ domain containing 2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; intestinal and kidney enriched PDZ protein; intestinal an
• UniProt Protein Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF4
• Protein Family: Na(+)/H(+) exchange regulatory cofactor
• UniProt Gene Name: PDZD3
• UniProt Synonym Gene Names: IKEPP; NHERF4; PDZK2; NHERF-4; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2
• UniProt Entry Name: NHRF4_HUMAN

NCBI Description

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]