Rabbit FKBP38 Polyclonal Antibody | anti-FKBP38 antibody

FKBP38 Antibody

Cat. Num. AAA840677

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: FKBP38; Polyclonal Antibody; FKBP38 Antibody; FKBPR38; FKBP8; FKBP 8; FK506 binding protein 8; FKBP 38; anti-FKBP38 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: 100 ug (0.2mg/ml) protein A purified rabbit anti-FKBP38 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.1% BSA, 20% glycerol, and 0.02% thimerosal.; Appearance: Colorless liquid
• Concentration: 0.2 mg/ml (varies by lot)
• Sequence Length: 1209

• Applicable Applications for anti-FKBP38 antibody: Western Blot (WB)
• Application Notes: Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. The antibody recognizes a ~40 kDa band in samples from human, mouse and rat origins. Reactivity to other species has not been tested.
• Immunogen: Synthetic peptide surrounding amino acid 344 of mouse FKBP38
• Handling: The antibody solution should be gently mixed before use.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for anti-FKBP38 antibody

Background: FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis thromugh its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been smuggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation thromugh interactions with tuberous sclerosis genes.

NCBI and Uniprot Product Information

• NCBI GI #: 28395544
• Molecular Weight: 43,616 Da
• NCBI Official Full Name: Mus musculus FK506-binding protein 38 mRNA, complete cds
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP8
• UniProt Gene Name: Fkbp8
• UniProt Synonym Gene Names: Fkbp38; Sam11; PPIase FKBP8; 38 kDa FKBP; FKBP-38; mFKBP38; FKBP-8
• UniProt Entry Name: FKBP8_MOUSE

Uniprot Description

FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Chaperone; Isomerase; EC 5.2.1.8; Mitochondrial

Cellular Component: mitochondrial envelope; mitochondrion; membrane; integral to membrane; integral to endoplasmic reticulum membrane

Molecular Function: identical protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; isomerase activity

Biological Process: neural tube development; smoothened signaling pathway; camera-type eye development; protein peptidyl-prolyl isomerization; protein folding; apoptosis; multicellular organism growth; regulation of BMP signaling pathway; cell fate specification; dorsal/ventral pattern formation; regulation of gene expression; dorsoventral neural tube patterning; positive regulation of BMP signaling pathway; negative regulation of apoptosis