Rabbit PDZD3 Polyclonal Antibody | anti-PDZD3 antibody

PDZD3 Rabbit Polyclonal

Cat. Num. AAA7602529

• Gene Names: PDZD3; IKEPP; PDZK2; NHERF4
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PDZD3; Polyclonal Antibody; PDZD3 Rabbit Polyclonal; anti-PDZD3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 288

• Applicable Applications for anti-PDZD3 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: PDZ domain containing 3
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(Rat kidney tissue were subjected to SDS PAGE followed by western blot with MBS7602529 (PDZD3 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 1034575561
• NCBI GeneID: 79849
• NCBI Accession #: XP_016873826.1
• NCBI GenBank Nucleotide #: XM_017018337.1
• Molecular Weight: 24,105 Da
• NCBI Official Full Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X6
• NCBI Official Synonym Full Names: PDZ domain containing 3
• NCBI Official Symbol: PDZD3
• NCBI Official Synonym Symbols: IKEPP; PDZK2; NHERF4
• NCBI Protein Information: Na(+)/H(+) exchange regulatory cofactor NHE-RF4
• UniProt Protein Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF4
• Protein Family: Na(+)/H(+) exchange regulatory cofactor
• UniProt Gene Name: PDZD3
• UniProt Synonym Gene Names: IKEPP; NHERF4; PDZK2; NHERF-4; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2
• UniProt Entry Name: NHRF4_HUMAN

NCBI Description

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]

Uniprot Description

PDZD3: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: apical part of cell; brush border; cytosol; subapical complex

Molecular Function: guanylate cyclase inhibitor activity; ion channel inhibitor activity; protein binding; protein C-terminus binding

Biological Process: cGMP-mediated signaling; ion transport; negative regulation of cGMP biosynthetic process; negative regulation of guanylate cyclase activity; receptor guanylyl cyclase signaling pathway; response to toxin; water transport