Rabbit anti-Human PDE6A Polyclonal Antibody | anti-PDE6A antibody

PDE6A, ID (PDE6A, PDEA, Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, PDE V-B1) (AP)

Cat. Num. AAA6332155

• Gene Names: PDE6A; PDEA; RP43; CGPR-A; PDE6A
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PDE6A; Polyclonal Antibody; ID (PDE6A; PDEA; Rod cGMP-specific 3'; 5'-cyclic phosphodiesterase subunit alpha; PDE V-B1) (AP); PDE V-B1; anti-PDE6A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-PDE6A antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the Central region of human PDE6A.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(PDE6A Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PDE6A antibody detected the PDE6A protein (arrow).)

Related Product Information for anti-PDE6A antibody

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Product Categories/Family for anti-PDE6A antibody

Antibodies; Enzymes; Phosphodiesterase

References

Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010). Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010). Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 170650674
• NCBI GeneID: 5145
• UniProt Accession #: P16499; Q0P638
• NCBI Official Full Name: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [Homo sapiens]
• NCBI Official Synonym Full Names: phosphodiesterase 6A, cGMP-specific, rod, alpha
• NCBI Official Symbol: PDE6A
• NCBI Official Synonym Symbols: PDEA; RP43; CGPR-A; PDE6A
• UniProt Protein Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
• Protein Family: Rod cGMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE6A
• UniProt Synonym Gene Names: PDEA
• UniProt Entry Name: PDE6A_HUMAN