Western Blot (WB)
(PDE6A Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PDE6A antibody detected the PDE6A protein (arrow).)
Rabbit PDE6A Polyclonal Antibody | anti-PDE6A antibody
PDE6A Antibody (Center)
Western Blot (WB)
(PDE6A Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PDE6A antibody detected the PDE6A protein (arrow).)
Western Blot (WB)
(PDE6A Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PDE6A antibody detected the PDE6A protein (arrow).)
phosphodiesterase 6A alpha subunit, expressed in cells of the
retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a
heterotrimer composed of an alpha, beta, and two gamma subunits.
cGMP is an important regulator of rod cell membrane current, and
its dynamic concentration is established by phosphodiesterase 6A
cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein
is a subunit of a key phototransduction enzyme and participates in
processes of transmission and amplification of the visual signal.
Mutations in this gene have been identified as one cause of
autosomal recessive retinitis pigmentosa.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010)
Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Uniprot Description
PDE6A: This protein participates in processes of transmission and amplification of the visual signal. Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43). RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the cyclic nucleotide phosphodiesterase family.
Protein type: EC 3.1.4.35; Phosphodiesterase
Chromosomal Location of Human Ortholog: 5q31.2-q34
Cellular Component: plasma membrane
Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; cytosolic calcium ion homeostasis; visual perception; retina development in camera-type eye; GMP metabolic process
Disease: Retinitis Pigmentosa 43
Research Articles on PDE6A
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Product Notes
The PDE6A pde6a (Catalog #AAA9205804) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 308-336. The PDE6A Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's PDE6A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PDE6A pde6a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDE6A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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