Rabbit PDE1C Polyclonal Antibody | anti-PDE1C antibody

PDE1C Antibody

Cat. Num. AAA540623

• Gene Names: PDE1C; Hcam3; hCam-3; cam-PDE 1C
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Synonyms: PDE1C; Polyclonal Antibody; PDE1C Antibody; 5''-cyclic nucleotide phosphodiesterase 1C; Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C; Cam PDE 1C; HCAM3; HSPDE1C1A; Human 3'5' cyclic nucleotide Phosphodiesterase; PDE 1C; Phosphodiesterase 1C; Phosphodiesterase 1C calmodulin dependent antibody; anti-PDE1C antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: This antibody does not cross-react with PDE1A, PDE1B, or other PDE family members. This antibody will label all PDE1C variants including PDE1C1, PDE1C2, and PDE1C3.
• Form/Format: Affinity Purified
• Concentration: 0.5 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 2694

• Applicable Applications for anti-PDE1C antibody: Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: Confocal Microscopy||1:40-1:100; Dot Blot: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:40-1:100; Immunofluorescence: 1:200; Immunohistochemistry: 1:40-1:100; Immunoprecipitation: 1:200; Western Blot: 1:500-1:2,000
• Immunogen: Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene.
• Expression: Expressed in several tissues, including brain and heart.
• Determinant: C-epitope
• Molecular Function: Hydrolase, calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, metal ion binding
• Structure: Homodimer
• Subcellular Location: Cytosol
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for anti-PDE1C antibody

Affinity Purified Pan Human 3', 5' cyclic nucleotide phosphodiesterase (HSPDE1C1A) Antibody C-epitope
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

Product Categories/Family for anti-PDE1C antibody

Primary Antibodies; Signal Transduction; Phosphodiesterases; PDE1C Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 1151110
• NCBI GeneID: 5137
• UniProt Accession #: Q14123; Q14124; Q8NB10; B3KPC6; E9PE92
• Molecular Weight: 86,896 Da
• NCBI Official Full Name: Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A) mRNA, complete cds
• NCBI Official Synonym Full Names: phosphodiesterase 1C
• NCBI Official Symbol: PDE1C
• NCBI Official Synonym Symbols: Hcam3; hCam-3; cam-PDE 1C
• NCBI Protein Information: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
• UniProt Protein Name: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
• Protein Family: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase
• UniProt Gene Name: PDE1C
• UniProt Synonym Gene Names: Cam-PDE 1C
• UniProt Entry Name: PDE1C_HUMAN

NCBI Description

Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).[supplied by OMIM, Oct 2009]

Uniprot Description

PDE1C: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.17; Phosphodiesterase; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: cytosol

Molecular Function: calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; metal ion binding

Biological Process: metabolic process; signal transduction