Mouse anti-Human PCLO Polyclonal Antibody | anti-PCLO antibody

PCLO (Protein Piccolo, Aczonin, ACZ, KIAA0559, DKFZp779G1236, KIAA0559)

Cat. Num. AAA645460

• Gene Names: PCLO; ACZ
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PCLO; Polyclonal Antibody; PCLO (Protein Piccolo; Aczonin; ACZ; KIAA0559; DKFZp779G1236; KIAA0559); Anti -PCLO (Protein Piccolo; anti-PCLO antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PCLO.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MKKFRVSLVSKVGKQKYVDLNMLSDSENSQHLELHEPPKAVDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTAHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEAAVQQLRIQPSKRRK

• Applicable Applications for anti-PCLO antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human PCLO, aa1-356 (AAH01304.2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PCLO expression in transfected 293T cell line by PCLO polyclonal antibody. Lane 1: PCLO transfected lysate (39.16kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-PCLO antibody

May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.

Product Categories/Family for anti-PCLO antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 150378539
• NCBI GeneID: 27445
• NCBI Accession #: NP_149015.2
• NCBI GenBank Nucleotide #: NM_033026.5
• UniProt Accession #: Q9Y6V0; O43373; O60305; Q08E72; Q9BVC8; Q9UIV2; Q9Y6U9; A4D1A7; A6NNX9
• Molecular Weight: 553,277 Da
• NCBI Official Full Name: protein piccolo isoform 1
• NCBI Official Synonym Full Names: piccolo presynaptic cytomatrix protein
• NCBI Official Symbol: PCLO
• NCBI Official Synonym Symbols: ACZ
• NCBI Protein Information: protein piccolo; aczonin; piccolo (presynaptic cytomatrix protein)
• UniProt Protein Name: Protein piccolo
• Protein Family: Protein piccolo
• UniProt Gene Name: PCLO
• UniProt Synonym Gene Names: ACZ; KIAA0559
• UniProt Entry Name: PCLO_HUMAN

NCBI Description

The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

piccolo: May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 7q21.11

Cellular Component: synaptic vesicle; cytoskeleton; membrane; postsynaptic density; synapse; cell junction

Molecular Function: calcium-dependent phospholipid binding; transporter activity; calcium ion binding; profilin binding

Biological Process: regulation of exocytosis; synaptic vesicle exocytosis; cAMP-mediated signaling; insulin secretion; cytoskeleton organization and biogenesis

Disease: Pontocerebellar Hypoplasia, Type 3