Goat PATJ Polyclonal Antibody | anti-Patj antibody
PATJ (INADL, InaD-like Protein, Inadl Protein, hINADL, Pals1-associated Tight Junction Protein, Protein Associated to Tight Junctions)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: ELISA: 1:32,000
NCBI and Uniprot Product Information
Uniprot Description
Function: Involved in cell polarity establishment. Probably participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Ref.9
Subunit structure: Component of the SAC complex, a complex composed of crb, Patj and sdt. Interacts directly with nrx via its third and fourth PDZ domains. Interacts directly with par-6, possibly mediating a link between the SAC complex and the par-6 complex, which is composed of par-6, baz and aPKC. Ref.1 Ref.3 Ref.7 Ref.8
Subcellular location: Membrane. Note: Membrane-associated. Localizes to the subapical domain of cells. Sdt is required for its localization. At mitotic cycles 13 and 14, during cellularization, it localizes at the leading edge of the invaginating membranes. It is then exclusively localized to the basal area of columnal epithelial cells. In the germline, it localizes at the membrane of the nurse cells during early and mid oogenesis. Later, it is found in the nuclear membrane in close association with actin filaments that connect the nuclei of the nurse cells with the plasma membrane. Ref.1 Ref.3
Tissue specificity: Expressed in primary and some secondary epithelial cells such as ectodermal cells, salivary glands, foregut, hindgut and invaginating tracheal cells. Also expressed in specific cells of the peripheral nervous system. Expressed in the germline. Ref.1 Ref.3
Developmental stage: Expressed both maternally and zygotically. Appears in mitotic cycle 11 when the furrows made by the imprint of the embryonic nuclei become apparent. Ref.1
Sequence similarities: Belongs to the Patj family.Contains 1 L27 domain.Contains 4 PDZ (DHR) domains.
Caution: Was originally thought to be the Disks lost (Dlt) protein. However, Ref.9 showed that it is not the case and renamed it Patj. This drastically changes the first conclusions drawn about its essential function, since the mutant used contained defects for another protein, which is now called Dlt. If its association with proteins involved in cell polarization complexes is clear, Patj is not essential since its absence apparently does not lead to important defects.
Sequence caution: The sequence AAD43031.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on Patj
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Product Notes
The Patj patj (Catalog #AAA6006951) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The PATJ (INADL, InaD-like Protein, Inadl Protein, hINADL, Pals1-associated Tight Junction Protein, Protein Associated to Tight Junctions) reacts with Bovine, Canine, Human, Porcine and may cross-react with other species as described in the data sheet. AAA Biotech's PATJ can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Suitable for use in ELISA. Dilution: ELISA: 1:32,000. Researchers should empirically determine the suitability of the Patj patj for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PATJ, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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