Loading...

Skip to main content

Call us on + 1 (800) 604-9114 for more information about our products

Looking for specific datasheet Manual/COA/MSDS?
Request a Manual/COA/MSDS

Interested to get a quote about our products?
Request a Quote

Immunofluorescence (IF) (Immunofluorescent analysis of PC3 cells using MBS7050615 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Rabbit anti-Human PARG Polyclonal Antibody | anti-PARG antibody

PARG Antibody

Gene Names
BPHL; MCNAA; BPH-RP; VACVASE
Reactivity
Human
Applications
ELISA, Immunofluorescence
Purity
>95%, Protein G purified
Synonyms
PARG; Polyclonal Antibody; PARG Antibody; Poly(ADP-ribose) glycohydrolase; anti-PARG antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Sequence Length
274
Applicable Applications for anti-PARG antibody
ELISA (EIA), Immunofluorescence (IF)
Application Notes
IF: 1: 50-1: 200
Immunogen
Recombinant Human Poly(ADP-ribose) glycohydrolase protein (1-348AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21478 / sc-21480 / sc-21480 / sc-21481
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunofluorescence (IF)

(Immunofluorescent analysis of PC3 cells using MBS7050615 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Immunofluorescence (IF) (Immunofluorescent analysis of PC3 cells using MBS7050615 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Related Product Information for anti-PARG antibody
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed: 23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed: 23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed: 23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed: 27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed: 27257257).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
670
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
54,794 Da
NCBI Official Full Name
valacyclovir hydrolase isoform 2
NCBI Official Synonym Full Names
biphenyl hydrolase like
NCBI Official Symbol
BPHL
NCBI Official Synonym Symbols
MCNAA; BPH-RP; VACVASE
NCBI Protein Information
valacyclovir hydrolase
UniProt Protein Name
Poly(ADP-ribose) glycohydrolase
UniProt Gene Name
PARG
UniProt Entry Name
PARG_HUMAN

NCBI Description

This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

Uniprot Description

PARG: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Belongs to the poly(ADP-ribose) glycohydrolase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.1.143; Hydrolase

Chromosomal Location of Human Ortholog: 10q11.23

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm; nucleus

Molecular Function: poly(ADP-ribose) glycohydrolase activity; protein binding

Research Articles on PARG

Similar Products

Product Notes

The PARG parg (Catalog #AAA7050615) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PARG Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PARG can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF). IF: 1: 50-1: 200. Researchers should empirically determine the suitability of the PARG parg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PARG, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Item has been added to Shopping Cart

If you are ready to order, navigate to Shopping Cart and get ready to checkout.

Looking for a specific manual?
Request a Manual

Request more Information

Please complete the form below and a representative will contact you as soon as possible.

Request a Manual

Please complete the form below and a representative will contact you as soon as possible.

Request a Quote

Please complete the form below and a representative will contact you as soon as possible.