Western Blot (WB)
(Anti-PAK1 antibody, MBS175263, Western blottingLane 1: Rat Testis Tissue LysateLane 2: Rat Spleen Tissue LysateLane 3: SW620 Cell LysateLane 4: MCF-7 Cell LysateLane 5: CEM Cell LysateLane 6: HT1080 Cell Lysate )
Rabbit PAK1 Polyclonal Antibody | anti-PAK1 antibody
Anti-PAK1 antibody
Western Blot (WB)
(Anti-PAK1 antibody, MBS175263, Western blottingLane 1: Rat Testis Tissue LysateLane 2: Rat Spleen Tissue LysateLane 3: SW620 Cell LysateLane 4: MCF-7 Cell LysateLane 5: CEM Cell LysateLane 6: HT1080 Cell Lysate )
Western Blot (WB)
(Anti-PAK1 antibody, MBS175263, Western blottingLane 1: Rat Testis Tissue LysateLane 2: Rat Spleen Tissue LysateLane 3: SW620 Cell LysateLane 4: MCF-7 Cell LysateLane 5: CEM Cell LysateLane 6: HT1080 Cell Lysate )
Background: Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene. PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activated kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternative transcripts of this gene have been found, but their full-length natures have not yet been determined. The PAK1 gene is mapped to 11q13-q14 by inclusion within a mapped clone.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Uniprot Description
PAK1: a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; PAKA subfamily
Chromosomal Location of Human Ortholog: 11q13-q14
Cellular Component: Golgi apparatus; nuclear membrane; protein complex; focal adhesion; dendrite; intercellular junction; cytosol; Z disc; ruffle; filamentous actin; growth cone; axon; cytoplasm; plasma membrane
Molecular Function: collagen binding; protein serine/threonine kinase activity; protein binding; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity
Biological Process: positive regulation of JNK activity; axon guidance; exocytosis; wound healing; apoptosis; protein amino acid autophosphorylation; positive regulation of estrogen receptor signaling pathway; receptor clustering; protein amino acid phosphorylation; T cell receptor signaling pathway; positive regulation of stress fiber formation; ephrin receptor signaling pathway; dendrite development; neuromuscular junction development; MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; branching morphogenesis of a tube; cellular response to insulin stimulus; actin cytoskeleton reorganization; T cell costimulation; response to hypoxia; innate immune response; positive regulation of protein amino acid phosphorylation; mitotic cell cycle; vascular endothelial growth factor receptor signaling pathway; neurite morphogenesis
Research Articles on PAK1
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Product Notes
The PAK1 pak1 (Catalog #AAA175263) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-PAK1 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PAK1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the PAK1 pak1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAK1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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