Goat anti-Human OSBPL1A Polyclonal Antibody | anti-OSBPL1A antibody

OSBPL1A, CT (ORP1, Oxysterol-binding Protein-related Protein 1, ORP-1, OSBP-related Protein 1, OSBP8, OSBPL1, OSBPL1B)

Cat. Num. AAA6010028

• Gene Names: OSBPL1A; ORP1; ORP-1; OSBPL1B
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: OSBPL1A; Polyclonal Antibody; CT (ORP1; Oxysterol-binding Protein-related Protein 1; ORP-1; OSBP-related Protein 1; OSBP8; OSBPL1; OSBPL1B); Anti -OSBPL1A; anti-OSBPL1A antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human OSBPL1A. Species sequence homology: bovine, canine, mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-OSBPL1A antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: ELISA: 1:16,000; Western Blot: 0.5-2ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide C-YWDRNYFNLPDIY from the C-terminus of human OSBPL1A.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Brain, cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Antibody staining (0.5ug/ml) of Human Muscle lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)

Related Product Information for anti-OSBPL1A antibody

Oxysterols are oxygenated derivatives of cholesterol that have a number of biological effects and play a key role in the maintenance of the body cholesterol balance. ORP1 is a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that are believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase.

Product Categories/Family for anti-OSBPL1A antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 335353788
• NCBI GeneID: 114876
• NCBI Accession #: NP_001229437.1
• NCBI GenBank Nucleotide #: NM_001242508.1
• UniProt Accession #: Q9BXW6; Q9BZF5; Q9NW87; B7Z7D3
• Molecular Weight: 108,470 Da
• NCBI Official Full Name: oxysterol-binding protein-related protein 1 isoform 3
• NCBI Official Synonym Full Names: oxysterol binding protein-like 1A
• NCBI Official Symbol: OSBPL1A
• NCBI Official Synonym Symbols: ORP1; ORP-1; OSBPL1B
• NCBI Protein Information: oxysterol-binding protein-related protein 1; OSBP-related protein 1; oxysterol binding protein-like 1B; oxysterol-binding protein-related protein 1 variant 1; oxysterol-binding protein-related protein 1 variant 2
• UniProt Protein Name: Oxysterol-binding protein-related protein 1
• Protein Family: Oxysterol-binding protein-related protein
• UniProt Gene Name: OSBPL1A
• UniProt Synonym Gene Names: ORP1; OSBP8; OSBPL1; OSBPL1B; ORP-1
• UniProt Entry Name: OSBL1_HUMAN

NCBI Description

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

OSBPL1A: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Belongs to the OSBP family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18q11.1

Cellular Component: nucleoplasm; lysosomal membrane; late endosome; cytoplasm; intracellular; nucleus

Molecular Function: protein binding; cholesterol binding; phospholipid binding

Biological Process: vesicle-mediated transport; cholesterol metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; lipid transport