Rabbit ORP1 Monoclonal Antibody | anti-OSBPL1A antibody

ORP1 Rabbit mAb

Cat. Num. AAA4752926

• Gene Names: OSBPL1A; ORP1; ORP-1; OSBPL1B
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay, Immunoprecipitation
• Purity: Affinity purified
• Synonyms: ORP1; Monoclonal Antibody; ORP1 Rabbit mAb; Oxysterol-binding protein-related protein 1; anti-OSBPL1A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: R02-2E2
• Purity/Purification: Affinity purified
• Form/Format: Supplied in 50nM Tris-Glycine (pH7.4), 0.15M Nacl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

• Applicable Applications for anti-OSBPL1A antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
• Application Notes: WB: 1:1000; ICC/IF: 1:20; FC/FACS: 1:20; IP: 1:20
• Immunogen: A synthetic peptide of human ORP1
• Conjugation: Unconjugated
• Modification: Unmodification
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western blot detection of ORP1 in Rat Brain,C6,Hela cell lysates using ORP1 Rabbit mAb(1:1000 diluted). Predicted band size:109kDa. Observed band size: 109,50kDa.)

Related Product Information for anti-OSBPL1A antibody

Oxysterol-binding protein-related protein 1

NCBI and Uniprot Product Information

• NCBI GI #: 335353788
• NCBI GeneID: 114876
• NCBI Accession #: NP_001229437.1
• NCBI GenBank Nucleotide #: NM_001242508.1
• UniProt Accession #: Q9BXW6; Q9BZF5; Q9NW87; B7Z7D3
• Molecular Weight: 65,095 Da
• NCBI Official Full Name: oxysterol-binding protein-related protein 1 isoform 3
• NCBI Official Synonym Full Names: oxysterol binding protein-like 1A
• NCBI Official Symbol: OSBPL1A
• NCBI Official Synonym Symbols: ORP1; ORP-1; OSBPL1B
• NCBI Protein Information: oxysterol-binding protein-related protein 1; OSBP-related protein 1; oxysterol binding protein-like 1B; oxysterol-binding protein-related protein 1 variant 1; oxysterol-binding protein-related protein 1 variant 2
• UniProt Protein Name: Oxysterol-binding protein-related protein 1
• Protein Family: Oxysterol-binding protein-related protein
• UniProt Gene Name: OSBPL1A
• UniProt Synonym Gene Names: ORP1; OSBP8; OSBPL1; OSBPL1B; ORP-1; OSBP-related protein 1
• UniProt Entry Name: OSBL1_HUMAN

NCBI Description

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

OSBPL1A: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Belongs to the OSBP family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18q11.1

Cellular Component: nucleoplasm; lysosomal membrane; cytoplasm; late endosome; intracellular; nucleus

Molecular Function: protein binding; cholesterol binding; phospholipid binding

Biological Process: vesicle-mediated transport; cholesterol metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; lipid transport